Effects of varenicline nasal spray: A Synthesis of Findings from 12 Studies

  1. Home
  2. Effects of varenicline nasal spray
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effects of varenicline nasal spray: A Synthesis of Findings from 12 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effects of varenicline nasal spray: A Synthesis of Findings from 12 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Varenicline is a medication used to help people quit smoking. 10 found that there was no difference in smoking cessation effectiveness between 1mg and 0.5mg varenicline, both administered twice daily for 8 weeks. 5 reviewed studies and concluded that varenicline, when used at a maintenance dose, can lead to gastrointestinal side effects. 1 noted that varenicline has the potential to reduce nicotine cravings and withdrawal symptoms while decreasing the reinforcing effects of nicotine. 2 evaluated the potential for abuse of varenicline and found it to be unlikely. 8 found that the adverse effects of varenicline can lead to discontinuation of the medication. 3 showed that varenicline can attenuate some of the subjective and physiological effects of intravenous nicotine. 6 demonstrated that varenicline can improve lapses in attention among smokers preparing to quit. 9 studied the effect of lowering the dose of varenicline on alcohol self-administration in people with alcohol use disorders. 12 compared different combinations of varenicline, nicotine patch, and treatment duration, but found no significant differences in smoking cessation effectiveness. 7 showed that short-term varenicline administration can affect cortisol levels in healthy, non-smoking adults. 11 found that varenicline can be used by smokers who are not yet ready to quit to reduce the number of cigarettes they smoke. 4 demonstrated that varenicline can reduce cravings and perceived reward from smoking.

Benefits and Risks

Benefit Summary

Varenicline can help people quit smoking. 1 It can reduce nicotine cravings and withdrawal symptoms. 1 It can also reduce the reward associated with smoking. 4 This makes varenicline a good option for people who want to quit smoking.

Risk Summary

Varenicline can cause gastrointestinal side effects. 5 It can also lead to discontinuation of treatment due to adverse effects. 8 It's important to be aware of these risks when using varenicline.

Study Comparisons

Study Similarities

Many studies have shown that varenicline is effective in helping people quit smoking. 1 4 Many studies have also shown that it can reduce nicotine cravings. 1 4

Study Differences

Studies vary in terms of dosage, duration of treatment, and characteristics of the participants. 10 12 Therefore, direct comparisons of the results are challenging.

Consistency and Contradictions

Many studies show positive results regarding varenicline's effectiveness in helping people quit smoking. 1 4 However, there is no clear consensus on the optimal dosage or duration of treatment. 10 12

Application in Real Life

Varenicline can be a beneficial treatment option for people who want to quit smoking. 1 4 However, it is important to be aware of the risk of gastrointestinal side effects. 5 8 It is essential to consult with a doctor and follow their instructions when using varenicline.

Limitations of Current Research

Further research is needed to evaluate the long-term safety and efficacy of varenicline. 8 Additionally, more research is needed to understand how varenicline impacts specific populations.

Future Research Directions

More studies are needed to determine the optimal dosage and duration of treatment for varenicline. 10 12 Long-term follow-up studies are also needed to evaluate the safety and efficacy of varenicline over time. 8

Conclusion

Varenicline can be a helpful treatment for people trying to quit smoking. 1 4 It is important to be aware of the potential side effects. 5 8 If you are considering using varenicline, it is crucial to talk to your doctor.

Literature analysis of 12 papers
Positive Content
10
Neutral Content
0
Negative Content
2
Article Type
10
2
0
1
12
1.

Smoking cessation efficacy and safety of varenicline, an alpha4beta2 nicotinic receptor partial agonist.

Author: TonstadSerena

Nicotine craving relief
Smoking cessation
Nicotine withdrawal

Varenicline, an alpha4beta2 nicotinic receptor partial agonist, has shown promising results in Phase 3 studies for inducing smoking cessation and maintaining smoking abstinence. It has the potential to relieve nicotine craving and withdrawal symptoms while reducing the reinforcing effects of nicotine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Human abuse liability of the smoking cessation drug varenicline in smokers and nonsmokers.

Author: McCollS L, BursteinA H, ReevesK R, BillingC B, StolarM, SellersE M

Smoking cessation
Abuse potential

Varenicline, a medication to help people stop smoking, is unlikely to be abused. This was demonstrated in a study where smokers and nonsmokers were given varenicline or a placebo. Varenicline did not produce the same pleasurable effects as amphetamine, a known drug of abuse. Additionally, varenicline was associated with some unpleasant effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans.

Author: SofuogluMehmet, HermanAryeh I, MooneyMarc, WatersAndrew J

Smoking cessation

This study characterized the effects of varenicline, a partial nicotinic acetylcholine receptor (nAChR) agonist used for smoking cessation, on nicotine's dose-dependent effects in abstinent smokers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

4.

Varenicline effects on craving, cue reactivity, and smoking reward.

Author: BrandonThomas H, DrobesDavid J, UnrodMarina, HeckmanBryan W, OliverJason A, RoetzheimRichard C, KarverSloan Beth, SmallBrent J

Reduced reward from smoking
Reduced tobacco cravings
None mentioned

Varenicline reduced tonic craving, cue-provoked craving, the expected value of cigarettes, number of puffs and time spent smoking, and self-reported reward from smoking compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Gastrointestinal adverse effects of varenicline at maintenance dose: a meta-analysis.

Author: LeungLawrence K, PatafioFrancis M, RosserWalter W

gastrointestinal adverse effects

Varenicline is a medication that helps people quit smoking. It can cause gastrointestinal side effects such as nausea, vomiting, and diarrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

The effects of varenicline on attention and inhibitory control among treatment-seeking smokers.

Author: RhodesJessica D, HawkLarry W, AshareRebecca L, SchlienzNicolas J, MahoneyMartin C

Smoking cessation

Varenicline improved lapses in attention among treatment-seeking smokers preparing to make a quit attempt, suggesting that attention may play a role in its mechanism of action for smoking cessation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Effects of short-term varenicline administration on cortisol in healthy, non-smoking adults: a randomized, double-blind, study.

Author: MockingRoel J T, WeverStephany A, PflanzC Patrick, PringleAbbie, ParsonsElizabeth, McTavishSarah F, CowenPhil J, HarmerCatherine J, ScheneAart H

Effective smoking cessation
Depressogenic side effects

Varenicline is a highly effective drug for smoking cessation, but it has been linked to depression in some users. It remains unclear whether this is due to varenicline itself, or to smoking and/or smoking cessation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Adverse Effects Cause Varenicline Discontinuation: A Meta-Analysis.

Author: DrovandiAaron D, ChenCarla C, GlassBeverley D

Smoking cessation
Discontinuation

Varenicline is a smoking cessation drug that is effective in providing prolonged smoking abstinence. However, its adverse effect profile may cause discontinuation, potentially reducing smoking abstinence rates.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

9.

Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders.

Author: VerplaetseTerril L, PittmanBrian P, ShiJulia M, TetraultJeanette M, CoppolaSabrina, McKeeSherry A

Alcohol consumption reduction
Insomnia

This double-blind, placebo-controlled trial examined the effect of varenicline (1 and 2 mg/day) on alcohol consumption in adults with alcohol use disorders. The 2 mg/day dose reduced alcohol craving but did not significantly reduce alcohol consumption. The 1 mg/day dose had no significant effect on craving or consumption.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

10.

Effect of 0.5 mg versus 1 mg varenicline for smoking cessation: a randomized controlled trial.

Author: Fouz-RosónNatalia, Montemayor-RubioTeodoro, Almadana-PachecoVirginia, Montserrat-GarcíaSoledad, Gómez-BasteroAna Paulina, Romero-MuñozConcepción, Polo-PadilloJuan

Side effects

This open-label randomized trial compared the effectiveness of 1 mg and 0.5 mg varenicline in smoking cessation. The study found that both doses were equally effective in achieving abstinence at 1 year, with similar rates of adherence and side effects. This suggests that a lower dose of varenicline may be just as effective as a higher dose for smoking cessation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Varenicline for smoking reduction in smokers not yet ready to quit: A double-blind, proof-of-concept randomized clinical trial.

Author: SteinbergMarc L, LuShou-En, WilliamsJill M

Quitting self-efficacy
Smoking reduction

Varenicline is a promising treatment option for smokers who are willing to reduce but not quit smoking. While varenicline did not lead to a significant reduction in cigarettes per day compared to placebo, it did increase the number of smokers who made a quit attempt. Successful reduction in cigarettes per day was associated with increased self-efficacy for quitting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial.

Author: BakerTimothy B, PiperMegan E, SmithStevens S, BoltDaniel M, SteinJames H, FioreMichael C

Insomnia
Nausea

This randomized clinical trial found no significant difference in smoking cessation rates at 52 weeks between varenicline monotherapy and combined varenicline plus nicotine patch therapy, or between 12-week and 24-week treatment durations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.