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Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study.

Author: AngiolilloDominick J, BassTheodore A, CapodannoDavide, CharltonRonald K, DarlingtonAndrew, DesaiBhaloo, DharmashankarKodlipet, FerreiroJosé Luis, KodaliMurali K, PhamJohn-Paul, SeecheranNaveen, Tello-MontoliuAntonio, TomaselloSalvatore D, UenoMasafumi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the impact of high-dose pantoprazole therapy, a proton pump inhibitor, on clopidogrel-mediated pharmacodynamic effects. The study aimed to determine whether the drug interaction between clopidogrel and proton pump inhibitors is a class effect or a drug effect and if timing of drug administration affects the interaction.
Paper Details　
Original Abstract of the Article :
Safety concerns have recently emerged based on a drug interaction between clopidogrel and proton pump inhibitors leading to reduced pharmacodynamic effects. However, whether such drug interaction is a class effect or a drug effect and if this can be modulated by timing of drug administration remains...See full text at original site
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引用元：
https://doi.org/10.1161/CIRCINTERVENTIONS.110.960997

データ提供：米国国立医学図書館（NLM）

Exploring the Impact of Pantoprazole on Clopidogrel Effects

This study investigates the potential for [drug interactions] between [clopidogrel], a medication used to prevent blood clots, and [proton pump inhibitors (PPIs)], commonly prescribed for heartburn and acid reflux. The study examines the impact of [pantoprazole], a PPI with low potential to interfere with clopidogrel metabolism, on clopidogrel-mediated pharmacodynamic effects. The study found that pantoprazole, whether administered concomitantly or staggered, did not significantly alter the pharmacodynamic effects of clopidogrel. This research provides evidence to support the safe use of pantoprazole in patients receiving clopidogrel treatment, offering reassurance for healthcare providers and patients.

Navigating Drug Interactions: Balancing Benefits and Risks

This study highlights the importance of carefully considering potential drug interactions when prescribing medications. It emphasizes the need for evidence-based guidelines and careful monitoring to ensure the safety and efficacy of drug combinations. Understanding the mechanisms of drug interactions is crucial for making informed treatment decisions and promoting patient safety.

The Importance of Personalized Medicine: Tailoring Treatment to Individual Needs

This research underscores the importance of personalized medicine, tailoring treatment plans to individual patient needs. Healthcare providers must consider factors such as patient history, medication use, and potential drug interactions to ensure optimal outcomes. This personalized approach can help minimize the risk of adverse effects and maximize the benefits of treatment.

Dr.Camel's Conclusion

This study provides valuable insights into the potential drug interactions between clopidogrel and pantoprazole, offering reassurance for healthcare providers and patients. It highlights the importance of evidence-based guidelines, careful monitoring, and personalized medicine in managing drug interactions to ensure patient safety and optimize treatment outcomes. As Dr. Camel, I believe that this research contributes to a safer and more effective approach to patient care.

Date :
  1. Date Completed 2011-10-24
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21521834

DOI: Digital Object Identifier

10.1161/CIRCINTERVENTIONS.110.960997

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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