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Varenicline effects on craving, cue reactivity, and smoking reward.
Author: BrandonThomas H, DrobesDavid J, HeckmanBryan W, KarverSloan Beth, OliverJason A, RoetzheimRichard C, SmallBrent J, UnrodMarina
Original Abstract of the Article :
RATIONALE: Varenicline is an α4β2 nicotinic acetylcholine receptor partial agonist that has been found to be effective for treating tobacco dependence. However, the subjective and behavioral mediators of its efficacy are not known. OBJECTIVES: Using multiple sessions of laboratory-based assessment,...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/21559801
データ提供:米国国立医学図書館(NLM)
Varenicline: A Hopeful Light for Smokers
The world of [smoking cessation] is a vast desert, with many struggling to escape the clutches of nicotine addiction. This research is like a refreshing oasis, offering a potential solution for those seeking relief. The study delves into the mechanisms behind [vare nicline], a medication used to treat [tobacco dependence], by employing a [double-blind, placebo-controlled experiment]. The researchers were on a mission to uncover how varenicline impacts [tonic and cue-provoked tobacco cravings] and [perceived reward from smoking]. Their findings revealed that varenicline effectively reduced both types of cravings and decreased the perceived pleasure associated with smoking, making it a potentially powerful tool for smoking cessation.
Varenicline's Effect on Cravings and Reward
The results are quite encouraging, as they show that varenicline not only reduces cravings but also lessens the perceived reward from smoking. This double-whammy could make quitting a much more manageable journey. Specifically, participants on varenicline reported significantly lower levels of [tonic craving] and [cue-provoked craving] compared to those on placebo. Moreover, varenicline led to a decrease in the [expected value of cigarettes] and a reduction in both [number of puffs] and [time spent smoking] - all positive signs for those looking to kick the habit.
The Promise of Varenicline
The results suggest that varenicline holds significant promise for those seeking to break free from [tobacco dependence]. It's like a cool desert breeze, offering a respite from the heat of addiction. By targeting both [cravings] and [reward], varenicline could be a game-changer in the fight against [tobacco dependence]. These findings provide further evidence to support the use of varenicline as a [therapeutic intervention] and could pave the way for more targeted approaches to combat [tobacco dependence].
Dr. Camel's Conclusion
Varenicline offers a glimmer of hope for smokers seeking freedom from addiction. It's like a camel finding an oasis in the desert, providing relief from the harsh realities of nicotine dependence. By tackling cravings and reward, varenicline could lead to a smoother and more successful quitting journey. The study's findings are a beacon of hope, encouraging further research into this promising medication.
Date :
- Date Completed 2012-02-21
- Date Revised 2022-03-10
Further Info :
English
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