Paper Details

  1. Home
  2. Paper Details

Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders.

Author: CoppolaSabrina, McKeeSherry A, PittmanBrian P, ShiJulia M, TetraultJeanette M, VerplaetseTerril L

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This double-blind, placebo-controlled trial examined the effect of varenicline (1 and 2 mg/day) on alcohol consumption in adults with alcohol use disorders. The 2 mg/day dose reduced alcohol craving but did not significantly reduce alcohol consumption. The 1 mg/day dose had no significant effect on craving or consumption.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: Varenicline (2 mg/d) has been shown to be efficacious in reducing alcohol consumption. A lower dose of varenicline may be effective in reducing alcohol use while minimizing the potential for side effects. METHODS: This double-blind, placebo-controlled investigation examined the effect o...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/27159341

データ提供：米国国立医学図書館（NLM）

Varenicline: A Potential Ally in Alcohol Dependence

The struggle with alcohol dependence is a complex and multifaceted challenge. This study explores the potential of varenicline, a medication commonly used for smoking cessation, in reducing alcohol consumption. The researchers investigated the effects of different doses of varenicline on alcohol craving and consumption in individuals with alcohol use disorders. The results suggest that a higher dose of varenicline (2 mg/day) may be more effective in reducing alcohol craving, but the study found no evidence supporting the effectiveness of a lower dose (1 mg/day). The study also explored the relationship between plasma varenicline levels and alcohol consumption, revealing potential correlations between higher levels and reduced drinking.

Dosage Matters: Finding the Right Balance

This study emphasizes the importance of finding the right dosage of varenicline for individuals struggling with alcohol dependence. The findings suggest that lower doses may not be effective in reducing alcohol consumption and that higher doses may be needed for optimal results. These insights highlight the need for personalized treatment approaches, tailoring medication dosages to individual needs and responses.

Navigating the Path to Sobriety

This research offers a glimmer of hope for those seeking to overcome alcohol dependence. It suggests that varenicline, a medication traditionally used for smoking cessation, may have potential benefits in reducing alcohol consumption. While further research is needed to fully understand the optimal dosage and effectiveness of varenicline in treating alcohol use disorders, this study provides valuable insights into potential treatment strategies.

Dr.Camel's Conclusion

Imagine a desert with two oases, my friend. This study suggests that while both oases can offer relief, the higher dose might be more effective in quenching our thirst for alcohol.

Date :
  1. Date Completed 2017-02-13
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

27159341

DOI: Digital Object Identifier

NIHMS760408

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.