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Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.

Author: IsaacMokhtar Gad El Kareem Nasr, JaturapatpornDarin, McCleeryJenny, TabetNaji

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Aspirin, steroids, and NSAIDs did not demonstrate significant improvement in cognitive decline in Alzheimer's disease (AD) patients. Aspirin was associated with increased bleeding, steroids with hyperglycemia and abnormal lab results, and NSAIDs with nausea, vomiting, and elevated creatinine levels.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia. The incidence of AD rises exponentially with age and its prevalence will increase significantly worldwide in the next few decades. Inflammatory processes have been suspected in the pathogenesis of the disease. OBJECTIVES: To ...See full text at original site
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引用元：
https://doi.org/10.1002/14651858.CD006378.pub2

データ提供：米国国立医学図書館（NLM）

Aspirin, Steroids, and NSAIDs: A Quest for Alzheimer's Treatment

This research embarks on a quest to understand the potential role of anti-inflammatory medications in the management of Alzheimer's disease (AD), a devastating neurodegenerative disorder. The study reviews the efficacy and side effects of aspirin, steroids, and non-steroidal anti-inflammatory drugs (NSAIDs) in treating AD, comparing their effects to placebo. The authors conducted a comprehensive review of randomized controlled trials (RCTs) to assess the evidence for the effectiveness of these medications in AD.

Limited Evidence for Anti-Inflammatory Medications in AD

This review concludes that there is no conclusive evidence to support the use of aspirin, steroids, or NSAIDs for the treatment of AD. The studies included in the review did not demonstrate a significant improvement in cognitive decline with these medications. Furthermore, the review highlighted potential side effects associated with these medications, including bleeding, hyperglycemia, and gastrointestinal problems. The findings suggest that these medications are not currently recommended for the treatment of AD.

Navigating the Complexities of Alzheimer's Disease

This study underscores the complexities of Alzheimer's disease, a condition that continues to puzzle researchers. It's like navigating a vast desert of unknowns. While anti-inflammatory medications have shown promise in other conditions, this review suggests that they may not be effective in treating AD. More research is needed to explore alternative approaches to managing this debilitating disease. It's essential to consult with a healthcare professional for personalized advice and treatment options for AD.

Dr.Camel's Conclusion

As a researcher who has witnessed the vast and ever-changing landscape of medical science, I find this review a sobering reminder of the challenges we face in tackling complex diseases like Alzheimer's. While the quest for effective treatments continues, it's important to stay informed about the latest research findings and consult with a healthcare professional for guidance and support.
Date :
  1. Date Completed 2012-05-23
  2. Date Revised 2023-08-15
Further Info :

Pubmed ID

22336816

DOI: Digital Object Identifier

10.1002/14651858.CD006378.pub2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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