Effective treatment of headache: A Synthesis of Findings from 107 Studies

  1. Home
  2. Effective treatment of headache
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of headache: A Synthesis of Findings from 107 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of headache: A Synthesis of Findings from 107 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major research findings

Multiple studies have shown that alternative therapies such as acupuncture and massage can be effective in treating headaches. 14 found that both acupuncture and massage with relaxation resulted in significant improvement in pain ratings for patients with chronic headaches. Massage with relaxation was particularly effective for patients with migraine headaches compared to acupuncture. showed that manual therapy can reduce headache-related disability in patients with tension headaches. 74 recommends non-pharmacological treatments for headaches during pregnancy. However, it is important to note that headaches during pregnancy can sometimes be a symptom of a serious condition, so if the headache is severe, it's crucial to seek immediate medical attention.

Treatment summary

14 studied the effects of acupuncture and massage with relaxation for patients with chronic headaches. focused on the effectiveness of manual therapy for patients with tension headaches. 74 explored non-pharmacological treatments for headaches during pregnancy. 76 found that galcanezumab was effective in preventing episodic migraines. 68 showed that aspirin can be used for acute treatment of episodic tension headaches. 30 demonstrated the effectiveness of almotriptan for early treatment of migraines.

Benefits and risks

Benefits summary

There are various treatments available for headaches, including acupuncture, massage, relaxation therapy, manual therapy, and non-pharmacological therapies, which have shown effectiveness. These treatments can potentially reduce the frequency and intensity of headaches, leading to an improved quality of life. Non-pharmacological treatments are recommended for headaches during pregnancy.

Risk summary

Headache treatments may have side effects or risks associated with them. For instance, acupuncture and massage could cause pain or discomfort for some individuals. Manual therapy, if not performed by a qualified practitioner, may pose a risk of injury. Medication use during pregnancy requires caution. In cases of severe headaches, seeking immediate medical attention is essential.

Comparison between studies

Commonalities between studies

Many studies suggest that alternative therapies such as acupuncture, massage, relaxation therapy, and manual therapy can be effective in treating headaches. A shared benefit across these therapies is their potential to reduce the frequency and intensity of headaches, contributing to an improved quality of life.

Differences between studies

Each study has different focuses, including the type of headache, treatment methods, and evaluation criteria. It can be challenging to directly compare the results due to these variations. For instance, 14 compares acupuncture with massage and relaxation therapy, while focuses solely on manual therapy. Furthermore, each study evaluates different aspects. 14 assesses pain ratings, while looks at headache-related disability.

Consistency and contradictions in results

While numerous studies indicate the effectiveness of alternative therapies such as acupuncture, massage, and relaxation therapy in treating headaches, direct comparisons of the results are difficult due to the variation in headache types, treatment approaches, and evaluation methods across different studies. Therefore, further research is necessary to solidify the effectiveness of headache treatment methods.

Practical implications and precautions

There are various treatment options available for headaches. However, not every treatment works for everyone. It is important to find a treatment that suits your individual symptoms and body type. In cases of severe headaches, prompt medical evaluation is essential.

Limitations of current research

Research on the effectiveness of headache treatments is still insufficient. The variation in headache types, treatment methods, and evaluation criteria across studies makes direct comparisons challenging. Consequently, further research is needed to establish the effectiveness of headache treatment methods.

Directions for future research

To further advance research on the effectiveness of headache treatments, the following areas require further investigation:

  • Large-scale studies involving more patients
  • Studies comparing the effectiveness of treatment methods for different headache types
  • Studies evaluating the long-term effects of treatment methods

Conclusion

There are various treatment options for headaches, and each has shown some degree of effectiveness. However, not all treatments work for everyone. It is crucial to find a treatment that suits your individual symptoms and body type. If you experience severe headaches, immediate medical attention is necessary.

For those dealing with headaches, seeking appropriate treatment can improve your quality of life.

Treatment list

Acupuncture, massage, relaxation therapy, manual therapy, non-pharmacological therapy, galcanezumab, aspirin, almotriptan, oxygen, melatonin, triptan, naproxen, lidocaine, indomethacin, lamotrigine, topiramate, gabapentin, verapamil, methylprednisolone, methysergide, lithium, steroids, dexketoprofen, botulinum toxin type A, metoclopramide, diphenhydramine, amitriptyline, flupirtine, paracetamol, ibuprofen, acetylsalicylic acid

Keywords
Benefit Keywords
Cluster headache treatment
1
Tension headache treatment
2
Reduced headache activity
Reduced medication consumption
3
Improved function
Reduced headache intensity
4
Reduced depressive symptoms
Reduced headache frequency
5
Reduced headache frequency
Reduced headache intensity
6
Tension headache treatment
7
Effective treatment
Reduced headache
8
Oral sumatriptan migraine efficacy
9
Cost-effective headache treatment
Improved access to treatment
10
Headache remission
Placebo effect
11
Adjunct treatment
Migraine reduction
12
Analgesic reduction
Headache reduction
13
Improved pain
14
Headache treatment
15
Medication overuse headache treatment
16
Acute headache treatment
17
Headache reduction
18
Botulinum toxin efficacy
Cervical manipulation efficacy
TENS efficacy
19
Effective headache treatment
20
Reduced headache frequency
21
Laser acupuncture
22
Effective headache treatment
Reduced migraine headache
Reduced tension headache
23
Relaxation therapy
24
Pain-free status
25
Headache treatment
26
Treats SUNCT syndrome
Treats cluster headache
Treats paroxysmal hemicrania
27
Improved headache treatment
28
Reduced chronic headache
29
Early treatment efficacy
Reduced headache duration
30
Improved migraine treatment
32
Migraine headache prevention
33
Chronic headache treatment
34
Improved headache
35
Improved medication overuse headache
36
Migraine treatment
38
Headache treatment
39
Cluster headache treatment
Pain relief
40
Headache treatment
41
Cluster headache treatment
42
Headache treatment
43
Pain relief (NSAID
acetaminophen)
44
Migraine treatment
45
Improved PTHA
46
Headache reduction
Improved quality of life
Reduced medication use
47
Prednisone reduces rescue medication
48
Migraine treatment
Tension headache treatment
49
Cluster headache treatment
50
Chronic headache management
51
Cluster headache treatment
52
Tension headache relief
53
Migraine treatment
54
Reduces headache frequency
55
Changed patients' views
Feasible treatment
56
Migraine relief
57
Occipital nerve blocks
58
Reduced headache intensity
59
Migraine treatment
60
Effective for migraine
Safe
61
Ibuprofen for TTH
62
Efficacious headache treatment
63
CH prevention
CH treatment
65
Improved quality of life
Increased PPT
Reduced headache frequency
66
Headache relief
Triptan reduction
67
Migraine treatment
69
Withdrawal headache relief
70
Reduced headache frequency
71
Chronic migraine treatment
72
Headache improvement
73
Headache treatment
74
Headache relief
75
Migraine prevention
76
Headache treatment
77
Migraine treatment
Preventive medications
78
Improved functional impairment
Reduced abortive medication use
Reduced depression
Reduced headache duration
Reduced headache frequency
Reduced headache intensity
79
Improved headache treatment
80
Medication-overuse headache treatment
81
Improved NDPH treatment
82
Reduced headache
83
MOH treatment
85
Reduced headache pain
86
Reduced CH attack frequency
87
Reversion from CM to EM
88
Improved cluster headache relief
89
Multimodal non-pharmacologic approach for PTH
91
CGH pain relief
GONBs efficacy
92
Migraine treatment
93
Flunarizine
PIH treatment
Sumatriptan
94
Effective
Migraine treatment
95
Effective migraine treatment
96
Non-pharmacological treatments for TTH
97
Headache treatment
Ketorolac effectiveness
Metoclopramide effectiveness
98
Tension headache treatment
99
Migraine treatment
100
Reduced migraine frequency
Reduced migraine pain
101
rCCH ONS treatment
102
Headache prevention
Headache relief
103
Improved TTH symptoms
Reduced VAS scores
Reduced headache frequency
104
PCH treatment
105
Reduced headache duration
Reduced headache frequency
Reduced headache intensity
Reduced medication use
106
Improved quality of life
107
Risk Keywords
Amitriptyline side effects
7
No effect on pain intensity
13
Methodological shortcomings
15
Heterogeneity of studies
Limited research
20
Tension headache
22
Migraine headache
Recurrent tension headache
23
Conflicting evidence
Low quality studies
24
Headache
28
Not 100% effective
29
Dizziness
Nausea
30
Migraine headache
32
Side effects
38
Insufficient evidence for other treatments
44
Infection
Lead migration
47
Drug interactions
Limited evidence
No prevention
49
Patient guilt
Patient misconceptions
56
Headache disorders
58
Increased restlessness
61
Migraine severity
69
Steroid therapy debate
70
Headache disability
Medication overuse
73
Pregnancy complications
74
Headache relapse
75
Injection site reaction
76
Treatment challenging
90
Limited pharmacological options
91
Adverse events
92
Lack of evidence
Randomized controlled trials needed
94
Temporal numbness
95
Small sample size
Unblinded
96
Repeat surgery
106
Literature analysis of 107 papers
Positive Content
101
Neutral Content
2
Negative Content
4
Article Type
59
19
42
31
106
1.

Treatment of acute cluster headache with sumatriptan.

Author:

Cluster headache treatment

Sumatriptan, a drug used for migraine, is being investigated for its potential to treat cluster headaches due to similarities between the two conditions and positive results from a preliminary study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

A comparison of pharmacological (amitriptyline HCL) and nonpharmacological (cognitive-behavioral) therapies for chronic tension headaches.

Author: HolroydK A, NashJ M, PingelJ D, CordingleyG E, JeromeA

Tension headache treatment

A study of 41 patients with recurrent tension headaches found that both cognitive-behavioral therapy and amitriptyline were effective in reducing headache activity. Cognitive-behavioral therapy yielded slightly better outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Placebo-controlled evaluation of abbreviated progressive muscle relaxation and of relaxation combined with cognitive therapy in the treatment of tension headache.

Author: BlanchardE B, AppelbaumK A, RadnitzC L, MichultkaD, MorrillB, KirschC, HillhouseJ, EvansD D, GuarnieriP, AttanasioV

Reduced headache activity
Reduced medication consumption

This study compared the effectiveness of progressive muscle relaxation (PMR), PMR with cognitive therapy, a placebo (pseudomeditation), and no treatment in 66 patients with tension headaches. Both PMR alone and PMR with cognitive therapy led to significant improvement in headache frequency and severity compared to the control groups. While both active treatments were effective, there was a trend suggesting that adding cognitive therapy to PMR might lead to greater improvements. The study concludes that both PMR and PMR with cognitive therapy are effective treatments for tension headaches.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Health status in patients with tension headache treated with acupuncture or physiotherapy.

Author: CarlssonJ, AugustinssonL E, BlomstrandC, SullivanM

Improved function
Reduced headache intensity

This study compared the effectiveness of acupuncture and physiotherapy in treating chronic tension headaches in 62 women. Both treatments improved overall function and reduced headache frequency and severity. Physiotherapy showed greater improvements in overall function and mental well-being, while acupuncture was slightly less effective in reducing headache intensity. The improvement in headache intensity persisted for 7-12 months after treatment. The study suggests that both physiotherapy and acupuncture can be effective treatments for chronic tension headaches, but physiotherapy may offer broader benefits.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Cognitive therapy vs. self-management training in the treatment of chronic headaches.

Author: MartinP R, NathanP R, MilechD, van KeppelM

Reduced depressive symptoms
Reduced headache frequency

This study compared cognitive therapy for depression and self-management training for headaches in 55 patients with chronic headaches. Both treatments effectively reduced headache frequency and depressive symptoms. However, the two treatments were not equally effective for all patients. Self-management training was more effective for those with lower levels of depression, while cognitive therapy was more effective for those with more chronic headaches. The study suggests that cognitive therapy, or a similar approach, may be more beneficial for patients with chronic headaches and depressive symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Results of a controlled, experimental, outcome study of nondrug treatments for the control of migraine headaches.

Author: SargentJ, SolbachP, CoyneL, SpohnH, SegersonJ

Reduced headache frequency
Reduced headache intensity

A study of 136 people with headaches compared the effects of no treatment, autogenic phrases, electromyographic (EMG) biofeedback, and thermal biofeedback. All groups experienced a reduction in headache symptoms, with the no-treatment group showing the least improvement. Thermal biofeedback showed a trend towards greater improvement in headache frequency and intensity compared to EMG biofeedback and autogenic phrases. These findings suggest that while all methods may have some benefit, thermal biofeedback may be particularly promising for reducing headache symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Spinal manipulation vs. amitriptyline for the treatment of chronic tension-type headaches: a randomized clinical trial.

Author: BolineP D, KassakK, BronfortG, NelsonC, AndersonA V

Tension headache treatment
Amitriptyline side effects

Spinal manipulative therapy was an effective treatment for tension headaches, with sustained therapeutic benefit after treatment cessation. Amitriptyline therapy was slightly more effective in reducing pain during treatment but was associated with more side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Treatment of recurrent tension headache: a meta-analytic review.

Author: BogaardsM C, ter KuileM M

Effective treatment
Reduced headache

Cognitive therapy, relaxation, or electromyelographic (EMG) biofeedback alone or in combination with relaxation were more effective than no treatment or placebo for tension headaches. Pharmacological therapy was also better than no treatment, but comparable to placebo when using a headache diary. Treatment outcome was influenced more by patient characteristics than treatment characteristics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

9.

Oral sumatriptan in the treatment of recurrent headache.

Author: CadyR K, RubinoJ, CrummettD, LittlejohnT W

Oral sumatriptan migraine efficacy

Oral sumatriptan was effective in treating recurrent headaches within 24 hours of successful treatment with subcutaneous sumatriptan. It relieved moderate or severe recurrent headaches within 4 hours in up to 81% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Home-based behavioral treatments for chronic benign headache: a meta-analysis of controlled trials.

Author: HaddockC K, RowanA B, AndrasikF, WilsonP G, TalcottG W, SteinR J

Cost-effective headache treatment
Improved access to treatment

This study conducted a meta-analysis of controlled clinical trials examining the effectiveness of home-based treatments for chronic benign headache. The analysis suggested that home-based treatments produced comparable or, in some cases, superior results to clinic-based treatments, and were more cost-effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

[Response to prophylactic treatment of benign headache in children].

Author: GaraizarC, PratsJ M, ZuazoE

Headache remission
Placebo effect

Prophylaxis of common childhood headaches may be needed in less than half of patients with high headache frequency. School achievement can be a factor in compliance and headache persistence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

12.

Nonpharmacological treatment for migraine: incremental utility of physical therapy with relaxation and thermal biofeedback.

Author: MarcusD A, ScharffL, MercerS, TurkD C

Adjunct treatment
Migraine reduction

This study investigated the effectiveness of physical therapy (PT) as a treatment for migraine headaches and as an adjunct treatment for those who did not improve with relaxation training/thermal biofeedback (RTB). While PT alone was not effective, it may be a useful adjunct for patients who fail to improve with RTB.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Spinal manipulation in the treatment of episodic tension-type headache: a randomized controlled trial.

Author: BoveG, NilssonN

Analgesic reduction
Headache reduction
No effect on pain intensity

Spinal manipulation therapy did not show any additional benefit over soft tissue therapy alone in treating episodic tension-type headache. Both treatment groups experienced significant reductions in headache hours and analgesic use, suggesting a possible benefit from soft tissue therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Does psychological testing help to predict the response to acupuncture or massage/relaxation therapy in patients presenting to a general neurology clinic with headache?

Author: WylieK R, JacksonC, CrawfordP M

Improved pain

This study compared acupuncture and massage with relaxation for chronic headache. Both treatments showed significant improvement in pain ratings, with massage being more effective for migraine patients. Despite improvement, 13% of patients remained concerned about a more serious underlying cause of their headache, even after reassurance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Acupuncture for idiopathic headache.

Author: MelchartD, LindeK, FischerP, BermanB, WhiteA, VickersA, AllaisG

Headache treatment
Methodological shortcomings

Acupuncture may be beneficial for treating idiopathic headaches, but there is an urgent need for large-scale, well-planned studies to confirm its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Medication overuse headache.

Author: DienerH C, KatsaravaZ

Medication overuse headache treatment

Overusing migraine medications (more than 15 times a month) can lead to medication overuse headache. This can happen with analgesics, opioids, ergot alkaloids, and triptans, with the fastest onset for triptans (1-2 years), followed by ergot (3-5 years), and analgesics (5-10 years). Treatment involves gradually stopping the medications, followed by structured migraine treatment plans and preventive medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

[Acute treatment of episodic childhood tension-type headache with flupirtine and paracetamol - a double-blind crossover-study].

Author: PothmannR, LobischM

Acute headache treatment

About 10% of school-aged children experience migraine headaches, and 50% experience tension headaches. Common treatments for sudden headaches include pain relievers like paracetamol, acetylsalicylic acid (aspirin), or ibuprofen, with paracetamol being the most common choice for tension headaches in children. However, if these medications are ineffective or cause side effects, a safe alternative treatment is needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

18.

Cervicogenic headache: locus of control and success of treatment.

Author: StantonW R, JullG A

Headache reduction

Patients with high external locus of control scores for headaches were more likely to achieve a reduction in headache frequency if they received combined manipulative therapy and exercise therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Cervicogenic headaches: a critical review.

Author: HaldemanS, DagenaisS

Botulinum toxin efficacy
Cervical manipulation efficacy
TENS efficacy

This review summarizes the literature on cervicogenic headaches, which are headaches that originate from the cervical spine. The review discusses the historical perspective, diagnostic criteria, epidemiology, pathogenesis, differential diagnosis, and treatment of cervicogenic headaches. It concludes that there remains considerable controversy and confusion surrounding the topic, but that further research is needed to clarify the theory, diagnosis, and treatment options for patients with cervicogenic headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Non-invasive physical treatments for chronic/recurrent headache.

Author: BronfortG, NilssonN, HaasM, EvansR, GoldsmithC H, AssendelftW J J, BouterL M

Effective headache treatment
Heterogeneity of studies
Limited research

Non-invasive physical treatments, such as spinal manipulation, may be effective for treating chronic headaches, but more research is needed to confirm their effectiveness and cost-effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

The Trager approach in the treatment of chronic headache: a pilot study.

Author: FosterKimberley A, LiskinJack, CenSteven, AbbottAllan, ArmisenValeska, GlobeDenise, KnoxLyndee, MitchellMiles, ShtirCorina, AzenStanley

Reduced headache frequency

The Trager approach was found to be effective in decreasing headache frequency and medication usage in patients with chronic headache. It also improved headache quality of life, as did physician attention. Larger, multi-site studies are recommended to further confirm these findings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

The effects of laser acupuncture on chronic tension headache--a randomised controlled trial.

Author: EbneshahidiNarges Sadat, HeshmatipourMojtaba, MoghaddamiAlireza, Eghtesadi-AraghiPayam

Laser acupuncture
Tension headache

This study explores the effects of laser acupuncture on tension headaches, which are a common type of headache.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Relaxation treatment of adolescent headache sufferers: results from a school-based replication series.

Author: LarssonBo, CarlssonJane, FichtelAsa, MelinLennart

Effective headache treatment
Reduced migraine headache
Reduced tension headache
Migraine headache
Recurrent tension headache

Relaxation techniques have proven effective for children and teens with frequent tension headaches, while biofeedback is helpful for migraine sufferers, typically treated in specialized clinics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Conservative treatments of children with episodic tension-type headache. A systematic review.

Author: VerhagenArianne P, DamenLéonie, BergerMarjolein Y, PasschierJan, MerlijnVivian, KoesBart W

Relaxation therapy
Conflicting evidence
Low quality studies

Evidence on the effectiveness of conservative treatments for tension-type headaches (TTH) in children is conflicting. Relaxation therapy showed mixed results, while other interventions like biofeedback and cognitive therapy lack evidence.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Pain free efficacy of sumatriptan in the early treatment of migraine.

Author: JelinskiSusan E, BeckerWerner J, ChristieSuzanne N, AhmadFaiz E, Pryse-PhillipsWilliam, SimpsonScott D

Pain-free status

Sumatriptan 50 mg and 100 mg were significantly superior to placebo for pain relief at two hours in patients with migraine. Pain-free response rates were higher than in older trials where sumatriptan was administered after pain had reached moderate or severe intensity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Characteristics and treatment of headache after traumatic brain injury: a focused review.

Author: LewHenry L, LinPei-Hsin, FuhJong-Ling, WangShuu-Jiun, ClarkDavid J, WalkerWilliam C

Headache treatment

Headaches are common after head injuries, with some lasting over a year. Many of these headaches resemble tension headaches and migraines. While there is no standard treatment, many doctors treat post-traumatic headache (PTH) similar to primary headaches. The study highlights the need for more research, specifically well-controlled studies, to develop effective treatments for PTH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

EFNS guidelines on the treatment of cluster headache and other trigeminal-autonomic cephalalgias.

Author: MayA, LeoneM, AfraJ, LindeM, SándorP S, EversS, GoadsbyP J,

Treats SUNCT syndrome
Treats cluster headache
Treats paroxysmal hemicrania

This study provides evidence-based recommendations for treating cluster headache, paroxysmal hemicrania, and SUNCT syndrome, focusing on first-line treatments, prophylaxis, and alternative therapies.

GuidelineRecommendations and best practices developed by experts for healthcare professionals to refer to when making clinical judgments and providing care.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

The effectiveness of hospitalization in the treatment of paediatric idiopathic headache patients.

Author: LanziG, D'ArrigoS, TermineC, RossiM, Ferrari-GinevraO, MongelliA, MillulA, BeghiE

Improved headache treatment
Headache

Headaches are a common problem that significantly impact children's quality of life, leading to missed school and increased use of pain medications. This study was inspired by the observation that some children with headaches may benefit more from treatment in a hospital setting compared to outpatient care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Topiramate in patients with episodic migraine: reducing the risk for chronic forms of headache.

Author: LimmrothVolker, BiondiDavid, PfeilJoop, SchwalenSusanne

Reduced chronic headache
Not 100% effective

Preventive treatment with topiramate in patients with episodic migraine may reduce the risk of developing chronic forms of headache. In a pooled analysis of 3 trials, topiramate significantly reduced the number of headache days and the number of patients reporting an increase in headache days. It also reduced acute medication usage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Effect of pain intensity and time to administration on responsiveness to almotriptan: results from AXERT 12.5 mg Time Versus Intensity Migraine Study (AIMS).

Author: FreitagFrederick G, FinlaysonGary, RapoportAlan M, ElkindArthur H, DiamondMerle L, UngerJeffrey R, FisherAlan C, ArmstrongRobert B, HulihanJoseph F, GreenbergSteven J,

Early treatment efficacy
Reduced headache duration
Dizziness
Nausea

Early treatment for migraine headaches was significantly more effective in reducing total headache duration compared to standard treatment. In a cluster-randomized study, patients treated within 1 hour of headache onset, regardless of pain intensity, experienced shorter headache duration. The study also found that treating mild or moderate pain was just as effective as treating severe pain when treatment was initiated within 1 hour.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

Prednisolone does not reduce withdrawal headache: a randomized, double-blind study.

Author: BøeMagne G, MyglandAse, SalvesenRolf

Prednisolone has no effect on withdrawal headache in unselected patients with chronic daily headache and medication overuse.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Analysis of pooled data from two pivotal controlled trials on the efficacy of topiramate in the prevention of migraine.

Author: FreitagFred G, FordeGrace, NetoWalter, WangDaniel Z, SchmittJennifer, WuShu-Chen, HulihanJoseph

Improved migraine treatment
Migraine headache

Many people with migraine headaches should receive preventive treatment due to how often they have migraines and how disabling they are. This study examines the use of the anticonvulsant topiramate in two large, controlled trials for patients experiencing 3-12 migraine headaches per month.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Intravenous dexamethasone vs placebo as adjunctive therapy to reduce the recurrence rate of acute migraine headaches: a multicenter, double-blinded, placebo-controlled randomized clinical trial.

Author: DonaldsonDavid, SundermannRyan, JacksonRaymond, BastaniAveh

Migraine headache prevention

The efficacy of single-dose dexamethasone as adjunctive therapy for emergency medicine patients with migraine headache in preventing headache recurrence was investigated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Implanted occipital nerve stimulators.

Author: JasperJoseph F, HayekSalim M

Chronic headache treatment

Occipital nerve stimulation (ONS) is being investigated as a treatment modality for chronic refractory headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Headache classification by history has only limited predictive value for headache episodes treated in controlled trials with OTC analgesics.

Author: DienerH-C, PfaffenrathV, PagelerL, PeilH, AicherB, LiptonR B

Improved headache

This study investigated the consistency between the headache diagnosis based on medical history and a diary, as well as the effectiveness of acetylsalicylic acid + paracetamol + caffeine in treating headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Management of medication overuse headache: 1-year randomized multicentre open-label trial.

Author: HagenK, AlbretsenC, VilmingS T, SalvesenR, GrønningM, HeldeG, GravdahlG, ZwartJ-A, StovnerL J

Improved medication overuse headache

This study compared the effectiveness of early introduction of preventive treatment for medication overuse headache (MOH) without detoxification to abrupt withdrawal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Randomized evaluation of octreotide vs prochlorperazine for ED treatment of migraine headache.

Author: MillerMichael A, LevskyMarc E, EnslowWilliam, RosinAlex

This study compares the effectiveness of intravenous octreotide (a medication) to standard treatment with prochlorperazine for migraine headaches in an emergency department setting. The study aims to determine if octreotide could be a more effective treatment option for migraine headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

A placebo-controlled surgical trial of the treatment of migraine headaches.

Author: GuyuronBahman, ReedDeborah, KrieglerJennifer S, DavisJanine, PashminiNazly, AminiSaeid

Migraine treatment
Side effects

This study investigated the effectiveness of surgically deactivating three common migraine trigger points in a double-blind, controlled trial. The study found that this surgical approach was effective in reducing migraines for many people who did not respond to traditional treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Preliminary results, methodological considerations and recruitment difficulties of a randomised clinical trial comparing two treatment regimens for patients with headache and neck pain.

Author: De HertoghWillem, VaesPeter, DevroeyDirk, LouisPaul, CarpayHans, TruijenSteven, DuquetWilliam, OostendorpRob

Headache treatment

This study aimed to compare the effectiveness of usual care (UC) alone versus UC combined with manual therapy (MT) in patients with headache and neck pain. Due to low enrollment, the study was prematurely terminated. The study will report preliminary findings and discuss challenges encountered, offering recommendations for future research.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

40.

High-flow oxygen for treatment of cluster headache: a randomized trial.

Author: CohenAnna S, BurnsBrian, GoadsbyPeter J

Cluster headache treatment
Pain relief

High-flow inhaled oxygen was more effective than placebo in treating acute cluster headaches. In a study of 109 patients, 78% of those using oxygen were pain-free at 15 minutes, compared to 20% of those using placebo. There were no significant adverse effects.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Treating headache recurrence after emergency department discharge: a randomized controlled trial of naproxen versus sumatriptan.

Author: FriedmanBenjamin W, SolorzanoClemencia, EssesDavid, XiaShujun, HochbergMichael, DuaNiels, HeinsAlan, SassoPaul, BijurPolly E, LiptonRichard B, GallagherE John

Headache treatment

This study aims to compare the effectiveness of oral sumatriptan and naproxen in treating recurrent primary headache after emergency department (ED) discharge, recognizing the challenges of managing recurrent headaches after ED visits.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

42.

Triptans for acute cluster headache.

Author: LawSimon, DerrySheena, MooreR Andrew

Cluster headache treatment

Cluster headache is a rare but very painful and disabling condition that comes on quickly. There are few effective treatments, with inhaled oxygen being the main option. Other treatments, such as intranasal lidocaine and ergotamine, are less commonly used and studied. Triptans, which are effective for migraine headaches, may also be helpful for cluster headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Peripheral nerve blocks and trigger point injections in headache management - a systematic review and suggestions for future research.

Author: AshkenaziAvi, BlumenfeldAndrew, NapchanUri, NarouzeSamer, GrosbergBrian, NettRobert, DePalmaTraci, RosenthalBarbara, TepperStewart, LiptonRichard B,

Headache treatment

This study examines the use of interventional procedures like peripheral nerve blocks (PNBs) and trigger point injections (TPIs) for various headache disorders. While these procedures are widely used, there is limited high-quality research on their efficacy for specific headache syndromes and a lack of consensus on optimal techniques. Further studies are needed to clarify their role in headache management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

[Treatment of tension type headache: paracetamol and NSAIDs work: a systematic review].

Author: VerhagenArianne P, DamenLéonie, BergerMarjolein Y, LenssinckMarie-Louise B, PasschierJan, KroesBart W

Pain relief (NSAID
acetaminophen)
Insufficient evidence for other treatments

Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen were effective for short-term pain relief in patients with tension-type headache compared to placebo. Ibuprofen was associated with fewer side effects compared to other NSAIDs. Insufficient evidence exists to support or refute the effectiveness of preventive medication, physiotherapy, biofeedback, or cognitive behavioral therapy for tension-type headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Dutch

45.

A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine.

Author: CadyRoger K, GoldsteinJerome, NettRobert, MitchellRussell, BeachM E, BrowningRebecca

Migraine treatment

Migraine treatment needs vary greatly, with some attacks requiring immediate strong medication and others needing less urgent care. While triptans are a standard treatment, they have limitations, and many people seek alternative options. A study suggested that a combination of feverfew and ginger might be effective when taken early during mild migraine headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Systematic review of interventions for post-traumatic headache.

Author: WatanabeThomas K, BellKathleen R, WalkerWilliam C, SchomerKatherine

Improved PTHA

This review examines effective interventions for post-traumatic headache (PTHA) after traumatic brain injury (TBI), identifies gaps in the literature, and suggests areas for future research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Occipital nerve stimulation for chronic migraine: a randomized trial.

Author: SerraGerardo, MarchiorettoFabio

Headache reduction
Improved quality of life
Reduced medication use
Infection
Lead migration

Occipital nerve stimulation (ONS) appeared to be a safe and effective treatment for chronic migraine (CM) and medication overuse headache (MOH) patients, improving headache intensity, frequency, quality of life, and reducing drug intake.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind, placebo-controlled study.

Author: RabeKasja, PagelerLutz, GaulCharly, LamplChristian, KrayaTorsten, FoerderreutherStefanie, DienerHans-Christoph, KatsaravaZaza

Prednisone reduces rescue medication

Prednisone reduces rescue medication use during withdrawal in medication overuse headache, but does not decrease the severity or duration of withdrawal headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Primary headache in children and adolescents: update on pharmacotherapy of migraine and tension-type headache.

Author: BonfertMichaela, StraubeAndreas, SchroederAndreas Sebastian, ReilichPeter, EbingerFriedrich, HeinenFlorian

Migraine treatment
Tension headache treatment
Drug interactions
Limited evidence
No prevention

This review examined the use of medications to treat migraines and tension headaches in children. While several medications are available, high-quality evidence is limited, and there are currently no approved medications for preventing pediatric headaches. Treatment decisions should be made on a case-by-case basis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study: rationale and protocol of a randomised trial.

Author: WilbrinkLeopoldine A, TeernstraOnno P M, HaanJoost, van ZwetErik W, EversSilvia M A A, SpincemailleGeert H, VeltinkPeter H, MullenersWim, BrandRonald, HuygenFrank J P M, JensenRigmor H, PaemeleireKoen, GoadsbyPeter J, Visser-VandewalleVeerle, FerrariMichel D

Cluster headache treatment

Occipital nerve stimulation (ONS) may be an effective treatment for chronic cluster headaches that are resistant to medical treatment. This study will investigate the effectiveness of ONS using a new design that aims to address blinding issues in pain neuromodulation studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

A systematic review of behavioral headache interventions with an aerobic exercise component.

Author: BaillieLauren E, GabrieleJeanne M, PenzienDonald B

Chronic headache management

This review assessed the effectiveness of exercise as an adjunct to other behavioral treatments for chronic headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Triptans for acute cluster headache.

Author: LawSimon, DerrySheena, MooreR Andrew

Cluster headache treatment

This updated review examines various treatment options for cluster headache, a severely painful condition with limited validated therapies. While inhaled oxygen is the first-line therapy, the research explores the effectiveness of other treatments like intranasal lignocaine, ergotamine, and triptans.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Parenteral treatment of episodic tension-type headache: a systematic review.

Author: WeinmanDanielle, NicastroOlivia, AkalaOlabiyi, FriedmanBenjamin W

Tension headache relief

This systematic review investigated the efficacy of parenteral therapies other than salicylates or nonsteroidal anti-inflammatory drugs for acute tension-type headaches in patients who did not respond to analgesic therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Emerging therapies for chronic migraine.

Author: Proietti CecchiniAlberto, GrazziLicia

Migraine treatment

Chronic migraines that aren't caused by overuse of medication can be difficult to treat. While some medications are available, they can be ineffective or have unwanted side effects. New treatments for chronic migraines are needed. Recent research suggests that occipital nerve stimulation (ONS) and injections of botulinum toxin type A can help, with at least some improvement seen in many patients. More research is needed to identify the best candidates for these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

55.

Effect of manual therapy techniques on headache disability in patients with tension-type headache. Randomized controlled trial.

Author: Espí-LópezG V, Rodríguez-BlancoC, Oliva-Pascual-VacaA, Benítez-MartínezJ C, LluchE, FallaD

Reduces headache frequency

Combined suboccipital soft tissue inhibition and occiput-atlas-axis manipulation is more effective than either treatment alone for tension-type headache (TTH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

GPs' experiences with brief intervention for medication-overuse headache: a qualitative study in general practice.

Author: FrichJan C, KristoffersenEspen Saxhaug, LundqvistChristofer

Changed patients' views
Feasible treatment
Patient guilt
Patient misconceptions

Focus group interviews with 22 GPs found that they experienced challenges when trying to convince patients that medication used to treat and prevent headache could cause medication-overuse headache (MOH). They found that labeling MOH as a diagnosis opened up a space for change. GPs found that Brief Intervention (BI) was a feasible strategy to treat MOH and relied on a good alliance between the doctor and patient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Comparison of therapeutic effects of magnesium sulfate vs. dexamethasone/metoclopramide on alleviating acute migraine headache.

Author: ShahramiAli, AssarzadeganFarhad, HatamabadiHamid Reza, AsgarzadehMorteza, SarehbandiBaharak, AsgarzadehSetareh

Migraine relief

Magnesium sulfate was a more effective and fast-acting medication compared to a combination of dexamethasone/metoclopramide for the treatment of acute migraine headaches.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

58.

Occipital nerve blocks in the treatment of headaches: safety and efficacy.

Author: VoigtCrystal L, MurphyMaurice O

Occipital nerve blocks
Headache disorders

This study investigates the potential of occipital nerve blocks (ONBs) for managing acute headache episodes. While ONBs are used in specialty settings, the research explores their use as an alternative to opioids in primary and emergency care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Celecoxib vs prednisone for the treatment of withdrawal headache in patients with medication overuse headache: a randomized, double-blind clinical trial.

Author: TaghdiriFoad, ToghaMansoureh, Razeghi JahromiSoodeh, PaknejadSeyed Mohammad Hassan

Reduced headache intensity

This study found that celecoxib and prednisone were not different in reducing headache days or rescue medication intake during withdrawal in medication overuse headache (MOH). However, patients treated with celecoxib experienced lower headache intensity during the first 3 weeks after withdrawal.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

60.

Triptan-induced disruption of trigemino-cortical connectivity.

Author: KrögerInga L, MayArne

Migraine treatment

Sumatriptan, a 5-HT1B/D agonist (triptan) used for migraine, specifically targets headache and migraine without affecting pain in general. fMRI studies show that sumatriptan modulates functional coupling between trigeminal nuclei and higher brain areas, suggesting a specific functional inhibition of trigemino-cortical projections as a mechanism of action.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

61.

A Randomized Controlled Trial of Intravenous Haloperidol vs. Intravenous Metoclopramide for Acute Migraine Therapy in the Emergency Department.

Author: GaffiganMatthew E, BrunerDavid I, WasonCourtney, PritchardAmy, FrumkinKenneth

Effective for migraine
Safe
Increased restlessness

Intravenous haloperidol was as safe and effective as metoclopramide for the treatment of migraine headaches in the emergency department. It resulted in similar pain relief and required less frequent rescue medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Ibuprofen for acute treatment of episodic tension-type headache in adults.

Author: DerrySheena, WiffenPhilip J, MooreR Andrew, BendtsenLars

Ibuprofen for TTH

This review examines the use of ibuprofen for treating frequent episodic tension-type headache (TTH). TTH is a common condition, and ibuprofen is one of the analgesics frequently used for acute treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Indomethacin Responsive Headaches: Exhaustive Systematic Review with Pooled Analysis and Critical Appraisal of 81 Published Clinical Studies.

Author: BordiniEmilia C, BordiniCarlos A, WoldeamanuelYohannes W, RapoportAlan M

Efficacious headache treatment

This study explores the relationship between indomethacin (IMC) and headache treatment, examining its effectiveness for various headache disorders and the mechanisms behind its action.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

64.

Paracetamol (acetaminophen) for acute treatment of episodic tension-type headache in adults.

Author: StephensGuy, DerrySheena, MooreR Andrew

This research examines the use of paracetamol (acetaminophen) for treating frequent episodic tension-type headache (TTH). TTH is a common condition, and the study explores the effectiveness of paracetamol for managing headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Treatment of Cluster Headache: The American Headache Society Evidence-Based Guidelines.

Author: RobbinsMatthew S, StarlingAmaal J, PringsheimTamara M, BeckerWerner J, SchwedtTodd J

CH prevention
CH treatment

Sumatriptan subcutaneous, zolmitriptan nasal spray, and high-flow oxygen are recommended for acute treatment of cluster headache. Suboccipital steroid injections are recommended for prophylactic treatment.

GuidelineRecommendations and best practices developed by experts for healthcare professionals to refer to when making clinical judgments and providing care.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

66.

Effectiveness of a Treatment Involving Soft Tissue Techniques and/or Neural Mobilization Techniques in the Management of Tension-Type Headache: A Randomized Controlled Trial.

Author: Ferragut-GarcíasAlejandro, Plaza-ManzanoGustavo, Rodríguez-BlancoCleofás, Velasco-RoldánOlga, Pecos-MartínDaniel, Oliva-Pascual-VacaJesús, Llabrés-BennasarBartomeu, Oliva-Pascual-VacaÁngel

Improved quality of life
Increased PPT
Reduced headache frequency

The application of soft tissue and neural mobilization techniques to patients with frequent episodic tension-type headache (FETTH) or chronic tension-type headache (CTTH) resulted in significant improvements in pressure pain threshold, frequency and intensity of pain crises, and quality of life. The combination of both techniques was more effective than either technique alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Greater occipital nerve block in the treatment of triptan-overuse headache: A randomized comparative study.

Author: KaradaşÖ, ÖzönA Ö, ÖzçelikF, ÖzgeA

Headache relief
Triptan reduction

Repeated greater occipital nerve (GON) block was found to be effective in treating triptan-overuse headache (TOH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

68.

Aspirin for acute treatment of episodic tension-type headache in adults.

Author: DerrySheena, WiffenPhilip J, MooreR Andrew

This research examines the use of aspirin for treating episodic tension-type headache (TTH). TTH is a common condition, and the study explores the effectiveness of aspirin for managing headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Trajectory of Improvement in Children and Adolescents With Chronic Migraine: Results From the Cognitive-Behavioral Therapy and Amitriptyline Trial.

Author: KronerJohn W, PeughJames, Kashikar-ZuckSusmita M, LeCatesSusan L, AllenJanelle R, SlaterShalonda K, ZafarMarium, KabboucheMarielle A, O'BrienHope L, ShenkChad E, Kroon Van DiestAshley M, HersheyAndrew D, PowersScott W

Migraine treatment
Migraine severity

This study compared headache frequency trajectories between groups receiving cognitive-behavioral therapy (CBT) plus amitriptyline (CBT+A) and headache education (HE) plus amitriptyline (HE+A) in patients with chronic migraine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

70.

Treatment of withdrawal headache in patients with medication overuse headache: a pilot study.

Author: CevoliSabina, GianniniGiulia, FavoniValentina, TerlizziRossana, SancisiElisa, NicodemoMarianna, ZanigniStefano, Bacchi ReggianiMaria Letizia, PierangeliGiulia, CortelliPietro

Withdrawal headache relief
Steroid therapy debate

This abstract discusses the need to find a consensus on the best withdrawal procedure for medication overuse headache (MOH) and the role of steroid therapy. The study aims to evaluate the effectiveness of methylprednisolone or paracetamol in treating withdrawal headache in MOH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

71.

Tricyclic and Tetracyclic Antidepressants for the Prevention of Frequent Episodic or Chronic Tension-Type Headache in Adults: A Systematic Review and Meta-Analysis.

Author: JacksonJeffrey L, MancusoJosephine M, NickoloffSarah, BernsteinRebecca, KayCynthia

Reduced headache frequency

Tricyclic antidepressants (TCAs) are modestly effective in reducing chronic tension-type headache and are superior to buspirone. Tetracyclics appear to be ineffective in the prophylactic treatment of chronic tension-type headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Does myofascial and trigger point treatment reduce pain and analgesic intake in patients undergoing onabotulinumtoxinA injection due to chronic intractable migraine?

Author: GandolfiMarialuisa, GeroinChristian, ValèNicola, MarchiorettoFabio, TurrinaAndrea, DimitrovaEleonora, TamburinStefano, SerinaAnna, CastellazziPaola, MeschieriAndrea, RicardFrançois, SaltuariLeopold, PicelliAlessandro, SmaniaNicola

Chronic migraine treatment

Chronic migraines are often associated with muscle tension in the neck. While medication is the main treatment, rehabilitation therapies to address muscle tension and trigger points may be helpful for managing headache symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

73.

Headache in Idiopathic Intracranial Hypertension: Findings From the Idiopathic Intracranial Hypertension Treatment Trial.

Author: FriedmanDeborah I, QuirosPeter A, SubramanianPrem S, MejicoLuis J, GaoShan, McDermottMichael, WallMichael,

Headache improvement
Headache disability
Medication overuse

This study characterized the headache phenotype, headache-related disability, medical comorbidities, use of symptomatic headache medications, and headache response to study interventions in patients with idiopathic intracranial hypertension (IIH). Headache was present in 84% of patients and the most common headache phenotypes were migraine, tension-type headache, probable migraine, and probable tension-type headache. Headache disability was significantly associated with patient-reported quality of life in the physical, mental, and visual domains.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

74.

Headache and pregnancy: a systematic review.

Author: NegroA, DelaruelleZ, IvanovaT A, KhanS, OrnelloR, RaffaelliB, TerrinA, ReuterU, MitsikostasD D,

Headache treatment
Pregnancy complications

This systematic review summarizes existing data on headache and pregnancy, covering clinical headache phenotypes, treatment options, effects of medications on the child, complications, and diagnostics. It emphasizes the importance of early diagnosis and the need for a well-considered approach to medication use during pregnancy and breastfeeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

75.

An exploratory study of IV metoclopramide+diphenhydramine for acute post-traumatic headache.

Author: FriedmanBenjamin W, BabbushKayla, IrizarryEddie, WhiteDeborah, John GallagherE

Headache relief
Headache relapse

Intravenous metoclopramide 20mg+diphenhydramine 25mg is an effective and well-tolerated medication regimen for patients presenting to the ED with acute post-traumatic headache, but one-third of patients reported headache relapse after ED discharge, and one-fourth of patients reported persistent headaches one week later.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

76.

Evaluation of Galcanezumab for the Prevention of Episodic Migraine: The EVOLVE-1 Randomized Clinical Trial.

Author: StaufferVirginia L, DodickDavid W, ZhangQi, CarterJeffrey N, AilaniJessica, ConleyRobert R

Migraine prevention
Injection site reaction

Galcanezumab 120-mg and 240-mg monthly injections significantly reduced monthly migraine headache days compared with placebo. The incidence rate of adverse events was low, demonstrating the favorable tolerability profile of galcanezumab.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

77.

A PRISMA-compliant systematic review of the endpoints employed to evaluate symptomatic treatments for primary headaches.

Author: García-AzorinD, YamaniN, MessinaL M, PeetersI, FerriliM, OvchinnikovD, SperanzaM L, MariniV, NegroA, BenemeiS, BarloeseM,

Headache treatment

This systematic review assesses the employed outcomes in clinical trials investigating primary headache treatments, focusing on acute pain cessation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

The Effect of Beginning Treatment With Fremanezumab on Headache and Associated Symptoms in the Randomized Phase 2 Study of High Frequency Episodic Migraine: Post-Hoc Analyses on the First 3 Weeks of Treatment.

Author: SilbersteinStephen D, RapoportAlan M, LoupePippa S, AycardiErnesto, McDonaldMirna, YangRonghua, BigalMarcelo E

Migraine treatment
Preventive medications

Migraine has a major impact on people's lives, affecting work and quality of life for both patients and families. Many people stop taking preventive migraine medications because it can take a long time to see improvement. This can lead to ineffective treatment.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

80.

Efficacy of psychological treatment for headache disorder: a systematic review and meta-analysis.

Author: LeeHye Jeong, LeeJin Hyeok, ChoEun Young, KimSun Mi, YoonSeoyoung

Improved headache treatment

This systematic review explored psychological treatments for primary headache disorders accessible in Korea, considering the global burden of headache and the need for diverse treatment approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Complete withdrawal is the most feasible treatment for medication-overuse headache: A randomized controlled open-label trial.

Author: EngelstoftIda Maria Storm, CarlsenLouise Ninett, MunksgaardSigne Bruun, NielsenMia, JensenRigmor Højland, BendtsenLars

Medication-overuse headache treatment

Medication overuse headache (MOH) is a type of headache that can occur when people take headache medications too often. This study looked at whether completely stopping headache medication or limiting medication use was more effective for reducing headache days.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

82.

New daily persistent headache: a systematic review on an enigmatic disorder.

Author: YamaniNooshin, OlesenJes

Improved NDPH treatment

This structured review provided an overview of new daily persistent headache (NDPH), a rare but treatment-refractory headache disorder, describing its epidemiology, clinical features, trigger factors, pathophysiology, diagnosis, and therapeutic options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Exercise, headache, and factors associated with headache in chronic whiplash: Analysis of a randomized clinical trial.

Author: Landén LudvigssonMaria, PetersonGunnel, WidhSimon, PeolssonAnneli

Reduced headache

Headache is a common symptom in chronic whiplash-associated disorders (WAD) and affects almost 40% of individuals after 5 years. This study investigated the effectiveness of different exercise approaches on headache in chronic WAD grades 2 and 3. The study also identified factors associated with headache and whether they differ based on the severity and bothersomeness of the headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

84.

Randomized Controlled Trials of Headache Treatments in Pregnancy: A Systematic Review.

Author: BushmanElisa T, CozziGabriella, SinkeyRachel G, SmithCatherine H, VarnerMichael W, DigreKathleen

This study aimed to summarize existing randomized controlled trials (RCTs) addressing headache treatment in pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Comparison of 3 Treatment Strategies for Medication Overuse Headache: A Randomized Clinical Trial.

Author: CarlsenLouise Ninett, MunksgaardSigne Bruun, NielsenMia, EngelstoftIda Maria Storm, WestergaardMaria Lurenda, BendtsenLars, JensenRigmor Højland

MOH treatment

A randomized clinical trial of 120 patients with medication overuse headache (MOH) found that all three treatment strategies (withdrawal plus preventive treatment, preventive treatment without withdrawal, and withdrawal with optional preventive treatment) were effective. However, withdrawal therapy combined with preventive medication from the start of withdrawal is recommended as treatment for MOH.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

86.

Physical Treatments Reduce Pain in Children with Tension-Type Headache: A Systematic Review and Meta-Analysis.

Author: BotMaria N, de WijerAnton, PoolJan, BronkhorstEwald M, KalaykovaStanimira Sparreboom, CreugersNico Hj, van de PutteElise M

Reduced headache pain

Physical treatments, particularly relaxation training and occlusal appliances, are effective in reducing pain in children with tension-type headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Treatment Outcomes in Patients Treated With Galcanezumab vs Placebo: Post Hoc Analyses From a Phase 3 Randomized Study in Patients With Episodic Cluster Headache.

Author: KudrowDavid, AndrewsJ Scott, RettigantiMallikarjuna, OakesTina, BardosJennifer, GaulCharly, RiesenbergRobert, WenzelRichard, KuruppuDulanji, MartinezJames

Reduced CH attack frequency

This study evaluated the median time-to-first occurrence of attack frequency reduction and impact on acute treatment management in patients with episodic cluster headache (CH). The study found that galcanezumab achieved faster response rates and lower frequency of acute medication use than placebo. Galcanezumab also had a greater proportion of patients achieving a clinically meaningful attack reduction.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

88.

Reversion From Chronic Migraine to Episodic Migraine in Patients Treated With Fremanezumab: Post Hoc Analysis From HALO CM Study.

Author: LiptonRichard B, CohenJoshua M, BibeauKristen, GalicMaja, SeminerioMichael J, Ramirez CamposVerena, Halker SinghRashmi B, AilaniJessica

Reversion from CM to EM

This study evaluated the effect of fremanezumab on the rate of reversion from chronic migraine (CM) to episodic migraine (EM). The study found that fremanezumab may offer the benefit of reversion from CM to EM, based on a reduction in the number of headache days over 3 months of treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

89.

Recently available and emerging therapeutic strategies for the acute and prophylactic management of cluster headache: a systematic review and expert opinion.

Author: ArgyriouAndreas A, VikelisMichail, MantovaniElisa, LitsardopoulosPantelis, TamburinStefano

Improved cluster headache relief

Cluster headache (CH) is an undertreated condition due to the lack of established treatment options. The review discusses recently published papers and ongoing trials on emerging pharmacological and interventional approaches for CH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Medical treatment of SUNCT and SUNA: a prospective open-label study including single-arm meta-analysis.

Author: LambruGiorgio, StubberudAnker, RantellKhadija, LagrataSusie, TronvikErling, MatharuManjit Singh

Treatment challenging

This study addressed the challenges in managing short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA) due to limited data and evidence-based treatment recommendations.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

91.

An updated brief overview on post-traumatic headache and a systematic review of the non-pharmacological interventions for its management.

Author: ArgyriouAndreas A, MitsikostasDimos-Dimitrios, MantovaniElisa, LitsardopoulosPantelis, PanagiotopoulosVasileios, TamburinStefano

Multimodal non-pharmacologic approach for PTH
Limited pharmacological options

Post-traumatic headaches (PTH), a common headache type that occurs after a head injury or whiplash, can be very difficult to live with. While there aren't many medications that work well for PTH, many patients find relief through a combination of non-medication approaches that address the physical, psychological, and social factors that contribute to their headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Efficacy and safety of greater occipital nerve block for the treatment of cervicogenic headache: a systematic review.

Author: CaponnettoValeria, OrnelloRaffaele, FrattaleIlaria, Di FeliceChiara, PistoiaFrancesca, LanciaLoreto, SaccoSimona

CGH pain relief
GONBs efficacy
Adverse events

Greater occipital nerve blocks (GONBs) showed promise in treating cervicogenic headache (CGH), with studies reporting pain reduction and few adverse events. However, larger and randomized studies are needed to confirm their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Treatment of postictal headache: a systematic review and future directions.

Author: ShahisavandiMina, ZeraatpishehZahra, RostaminejadMarzieh, Asadi-PooyaAli A

Flunarizine
PIH treatment
Sumatriptan
Lack of evidence
Randomized controlled trials needed

Postictal headache, a common and disabling condition in epilepsy, lacks effective treatment options. Flunarizine and sumatriptan show potential and warrant further investigation through well-designed randomized controlled trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

Comparison of Peripheral Neurectomy vs. Medical Treatment for Migraine: A Randomized Controlled Trial.

Author: BajajJitin, DoddamaniRamesh, ChandraSarat P, RatreShailendra, PariharVijay, YadavYadram, SharmaDhananjaya

Effective
Migraine treatment
Temporal numbness

This study found that migraine surgery using peripheral neurectomies was more effective than chronic drug treatment in appropriately selected patients. The surgery led to significant improvements in pain, disability, and headache frequency.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

96.

Intradermal mesotherapy versus intravenous dexketoprofen for the treatment of migraine headache without aura: a randomized controlled trial.

Author: AkbasIlker, KocakMeryem Betos, KocakAbdullah Osman, GurSultan Tuna Akgol, DogruyolSinem, DemirMehmet, CakirZeynep

Effective migraine treatment
Small sample size
Unblinded

A randomized controlled trial of 148 patients with migraine without aura in the emergency department found that intradermal mesotherapy was more efficacious than intravenous dexketoprofen in reducing pain intensity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

97.

Manual joint mobilisation techniques, supervised physical activity, psychological treatment, acupuncture and patient education for patients with tension-type headache. A systematic review and meta-analysis.

Author: KrøllLotte Skytte, CallesenHenriette Edemann, CarlsenLouise Ninett, BirkefossKirsten, BeierDagmar, ChristensenHenrik Wulff, JensenMette, TómasdóttirHanna, WürtzenHanne, HøstChristel Vesth, HansenJakob Møller

Non-pharmacological treatments for TTH

This study reviewed the evidence for non-pharmacological treatments for tension-type headache (TTH), including manual joint mobilization, supervised physical activity, psychological treatment, acupuncture, and patient education. These treatments are commonly used as supplements or alternatives to medication, but their effectiveness needs further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

Randomised trial of IV metoclopramide vs IV ketorolac in treatment of acute primary headaches.

Author: SoltaniKasra Morad, MotamedHassan, EslamiKaveh, MajdinasabNastaran, KoutiLeila

Headache treatment
Ketorolac effectiveness
Metoclopramide effectiveness

This study compared the effectiveness of metoclopramide and ketorolac for treating acute primary headaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

99.

Manual therapy in adults with tension-type headache: A systematic review.

Author: Cumplido-TrasmonteC, Fernández-GonzálezP, Alguacil-DiegoI M, Molina-RuedaF

Tension headache treatment

This systematic review aims to assess the effectiveness of manual and non-invasive therapies for treating tension-type headaches, the most common primary headache.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Current Evidence in Migraine Surgery: A Systematic Review.

Author: HenriquesSara, AlmeidaAlexandre, PeresHelena, Costa-FerreiraAntónio

Migraine treatment

Migraines are common and have a big impact on people's lives. While there are medications, some people don't respond well. Surgery to relieve pressure on nerves outside the brain has been suggested as an alternative, but doctors are still hesitant to use it.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

Effect of Auricular Acupuncture with Semi-Permanent Ear Needles on Controlling Migraine Symptoms: A Single-Blind Randomized Clinical Trial.

Author: HabibabadiMehran Razvani, AshtariFereshteh, RaeisiIman

Reduced migraine frequency
Reduced migraine pain

Auricular acupuncture with semi-permanent (ASP) needles may be a promising complementary therapy for migraine headaches. This single-blind, randomized controlled trial found that ASP acupuncture significantly reduced pain levels, frequency of migraine headaches, and nausea and vomiting compared to a control group. Patient satisfaction was also higher in the ASP acupuncture group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

102.

Preventive treatment of refractory chronic cluster headache: systematic review and meta-analysis.

Author: MembrillaJavier A, RoaJavier, Díaz-de-TeránJavier

rCCH ONS treatment

A systematic review and meta-analysis of 45 studies on preventive treatment for refractory chronic cluster headache (rCCH) found that occipital nerve stimulation (ONS) had a pooled response rate of 57.3% (95% CI 0.481-0.665). Deep brain stimulation (DBS) had a higher pooled response rate of 77.0% (95% CI 0.594-0.957) but also more serious adverse events. Other therapies showed weaker results or had less quality of evidence.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

103.

Effects on neuromodulation, acupuncture, and aerobic exercises on migraine and tension-type headache outcomes: A systematic review and meta-analysis.

Author: PiChenghui, LiuYinglu, LiLingling, TangWenjing, YanXin, YuShengyuan

Headache prevention
Headache relief

This systematic review and meta-analysis evaluated the effects of various non-pharmacological treatments for acute headaches, including neuromodulation, acupuncture, and aerobic exercises.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

105.

Expanding Our Role in Headache Management: A Systematic Review and Algorithmic Approach to Surgical Management of Postcraniotomy Headache.

Author: ShaffreyEllen C, SeitzAllison J, AlbanoNicholas J, IsraelJacqueline S, AfifiAhmed M

PCH treatment

This study examines the management of chronic postcraniotomy headache (PCH), a common and debilitating condition. The study includes a systematic review of the literature and a single-center case series to develop a treatment algorithm for this condition.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

106.

Efficacy of Occipital Nerve Stimulation in Trigeminal Autonomic Cephalalgias: A Systematic Review.

Author: VeilleuxCatherine, KhousakounDevon, KwonChurl-Su, AmoozegarFarnaz, GirgisFady

Reduced headache duration
Reduced headache frequency
Reduced headache intensity
Reduced medication use
Repeat surgery

Occipital nerve stimulation (ONS) may be an effective surgical treatment for medically refractory trigeminal autonomic cephalalgias (TACs), with a >50% reduction in attack frequency observed in approximately two-thirds of patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

107.

Quality of life in children suffering from headaches: a systematic literature review.

Author: OmbashiS, TsangarisE, HeeresA G, van RoeyV, NeuteboomR F, van Veelen-VincentM L C, JanssonK, MathijssenI M J, KlassenA F, VersnelS L

Improved quality of life

A systematic literature review identified 56 studies investigating quality of life (QoL) in pediatric headache patients. The most commonly used PROM was the PedsQL. Physical functioning, social wellbeing, and psychological wellbeing were the most common health concepts reported. There is a need for a condition-specific PROM to measure QoL in pediatric headache patients.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.