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A randomized, controlled, multicenter study to compare prazosin GITS with enalapril in hypertensive patients with diabetes mellitus. Bombay Hypertension Study Group.

Author: JoglekarS J, NanivadekarA S

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Prazosin GITS and enalapril were both effective in controlling hypertension in patients with diabetes mellitus. A randomized, controlled study involving 89 patients found that both drugs effectively lowered blood pressure. Prazosin GITS had a beneficial effect on serum triglycerides, while enalapril had a favorable effect on triglycerides but a detrimental effect on LDL cholesterol. Both drugs increased fasting blood sugar and 2-hour post-meal blood sugar levels, but this was more significant in the prazosin GITS group. Prazosin GITS was also associated with fewer adverse events compared to enalapril.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the long-term antihypertensive efficacy, tolerability, and metabolic effects of prazosin GITS and enalapril. DESIGN: Randomized, controlled, multicenter study of 26 weeks duration. SETTING: Office practices of 20 physicians in Mumbai, India. PATIENTS: Males and females, aged...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11233387

データ提供：米国国立医学図書館（NLM）

Comparing Antihypertensive Medications: Prazosin GITS vs Enalapril

The management of hypertension, particularly in patients with diabetes mellitus, is a crucial aspect of cardiovascular health. This study compares the long-term efficacy, tolerability, and metabolic effects of two antihypertensive medications, prazosin GITS and enalapril, in hypertensive patients with diabetes mellitus. The researchers conducted a randomized, controlled, multicenter study to assess the effectiveness and safety of these medications in this specific patient population.

Prazosin GITS Shows Promise for Hypertensive Patients with Diabetes

The study reveals that prazosin GITS, a long-acting form of prazosin, demonstrates comparable antihypertensive efficacy to enalapril. This finding holds significant implications for clinicians treating hypertensive patients with diabetes, offering a valuable alternative treatment option. It's like discovering a new oasis in the desert of hypertension, providing a refreshing source of relief and potential for improved cardiovascular health.

Navigating the Desert of Cardiovascular Health

The study underscores the importance of considering the metabolic effects of antihypertensive medications, particularly in patients with diabetes. It's like navigating the desert of cardiovascular health, where attention must be paid to the delicate balance of different factors. Prazosin GITS, in this study, demonstrated a favorable effect on certain lipid fractions, potentially contributing to better overall metabolic control. This research highlights the need for clinicians to carefully weigh the risks and benefits of different medications to optimize treatment outcomes for their patients.

Dr.Camel's Conclusion

This research provides valuable insights into the long-term efficacy and metabolic effects of prazosin GITS compared to enalapril in hypertensive patients with diabetes mellitus. The findings suggest that prazosin GITS represents a promising alternative for managing hypertension in this specific patient population. It’s like discovering a new path in the desert of cardiovascular health, offering a more effective and well-tolerated approach for achieving and maintaining healthy blood pressure levels.
Date :
  1. Date Completed 2001-05-03
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11233387

DOI: Digital Object Identifier

11233387

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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