Effects of short-term varenicline administration on cortisol in healthy, non-smoking adults: a randomized, double-blind, study.

Author: CowenPhil J, HarmerCatherine J, McTavishSarah F, MockingRoel J T, ParsonsElizabeth, PflanzC Patrick, PringleAbbie, ScheneAart H, WeverStephany A

Paper Details 
Original Abstract of the Article :
Varenicline is the most effective drug for smoking cessation, but its use decreased because of reports of depressogenic side effects. However, because smoking and smoking cessation on their own are associated with depression, it remains unclear whether reported depressogenic effects are attributable...See full text at original site
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引用元:
https://doi.org/10.1007/s00213-013-3213-7

データ提供:米国国立医学図書館(NLM)

Varenicline and Cortisol: A Complex Relationship

[Varenicline] is a medication used to help people quit smoking, but concerns have been raised about its potential [depressogenic side effects]. This study investigated the effects of [short-term varenicline administration] on [cortisol] levels in [healthy, non-smoking adults]. The researchers aimed to understand the relationship between [varenicline], [cortisol], and potential mood changes.

Exploring the Impact of Varenicline on Cortisol

The study found no significant effect of [varenicline] on [cortisol] levels in [healthy, non-smoking adults]. This finding suggests that [varenicline] may not directly influence [cortisol] levels, which are often linked to stress and mood regulation. The researchers suggest that the reported [depressogenic side effects] may be related to other factors, such as the complex interplay between [smoking], [smoking cessation], and [mood].

Navigating the Complexity of Smoking Cessation and Mood

This study emphasizes the complex relationship between [smoking], [smoking cessation], and [mood]. The findings suggest that [varenicline] may not be the primary driver of [depressogenic side effects], highlighting the need for further research to understand the underlying mechanisms. The researchers emphasize the importance of careful monitoring and personalized approaches to address the unique challenges faced by individuals attempting to quit smoking.

Dr. Camel's Conclusion

This study serves as a reminder that the journey to quit smoking can be a challenging and complex one. It emphasizes the need to consider individual factors and potential interactions between medications, lifestyle changes, and mood. Just as a camel navigates a desert landscape, we must approach smoking cessation with patience, understanding, and a comprehensive approach to support our patients.

Date :
  1. Date Completed 2014-08-18
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23892777

DOI: Digital Object Identifier

10.1007/s00213-013-3213-7

SNS
PICO Info
in preparation
Languages

English

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