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Rationale for a single-pill combination of perindopril arginine and amlodipine besylate.

Author: ElliottWilliam J

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A systematic review of 86 clinical trials involving perindopril, amlodipine, or other antihypertensive drugs showed that amlodipine was associated with a significant 24% increase in heart failure, but a significant decrease in cardiovascular events. Perindopril was associated with a significant reduction in all six cardiovascular endpoints.
Paper Details　
Original Abstract of the Article :
A systematic review identified 86 outcome-based clinical trials involving perindopril, amlodipine, or other antihypertensive drugs. In fixed-effects meta-analyses of 11 clinical trials (90,208 subjects), amlodipine was associated with a significant 24% increase in heart failure, but a significant de...See full text at original site
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引用元：
https://doi.org/10.1016/j.jash.2014.12.012

データ提供：米国国立医学図書館（NLM）

A Single-Pill Combination for Hypertension: Finding a Simple Solution in a Complex Desert

Hypertension, or high blood pressure, is a widespread condition, affecting millions worldwide. It's like a vast desert landscape, where imbalances in blood pressure can lead to serious health problems. This study explores the potential of a single-pill combination of perindopril arginine and amlodipine besylate, hoping to find a simple and effective solution for managing this complex condition.

Single-Pill Combination: An Oasis of Convenience

The researchers reviewed the existing evidence on the effectiveness and safety of perindopril and amlodipine, both commonly used antihypertensive drugs. They found that a single-pill combination of these medications could be a safe and effective option for managing hypertension, offering a more convenient approach for patients. This is like finding a single oasis in the desert of hypertension, providing a more accessible and efficient route to managing blood pressure.

Simplifying the Journey: A More Convenient Oasis

This study suggests that a single-pill combination of perindopril and amlodipine could be a valuable addition to the arsenal of hypertension treatments. This simple solution could improve adherence to medication and lead to better blood pressure control, making the journey through the hypertension desert less arduous and more manageable.

Dr.Camel's Conclusion

The desert of hypertension is a vast and complex landscape. A single-pill combination of perindopril and amlodipine offers a convenient oasis, simplifying the journey towards better blood pressure control and a healthier future.

Date :
  1. Date Completed 2016-01-15
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

25817217

DOI: Digital Object Identifier

10.1016/j.jash.2014.12.012

SNS
PICO Info
in preparation
Languages

English

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