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Side effect profile and comparative tolerability of 21 antidepressants in the acute treatment of major depression in adults: protocol for a network meta-analysis.

Author: BoadenKatharine, ChevanceAstrid, CiprianiAndrea, EfthimiouOrestis, FurukawaToshi A, ImaiHissei, KikuchiSino, KishimotoSanae, MatherSarah, NewEmma, OgawaYusuke, SalantiGeorgia, TajikaAran, TomlinsonAnneka

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study presents a protocol for a network meta-analysis comparing the efficacy, adverse events, and tolerability of all second-generation and selected first-generation antidepressants in the acute treatment of major depression in adults. The study aims to extend previous findings and update the evidence base for antidepressant treatment.
Paper Details　
Original Abstract of the Article :
We have recently compared all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Here we present a protocol for a network meta-analysis aimed at extending these results, updating the evidence base ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10270374/

データ提供：米国国立医学図書館（NLM）

Antidepressants - Comparing Efficacy and Tolerability

The desert of antidepressant research is vast and complex, with a wide range of medications available for treating major depression. This study outlines a protocol for a network meta-analysis aimed at comparing the efficacy and tolerability of various antidepressants, including both second-generation and selected first-generation options. The authors aim to provide a comprehensive overview of the adverse event profiles associated with these medications, helping clinicians and patients make informed decisions about treatment. This research is like a camel navigating a labyrinthine desert, carefully mapping out the different paths and potential outcomes associated with each medication.

Finding the Right Antidepressant

This network meta-analysis holds the potential to provide valuable insights into the relative efficacy and tolerability of different antidepressants, helping clinicians make more informed decisions about treatment. This research could be a valuable guide for those seeking to find the most effective and tolerable antidepressant, ensuring that their journey toward improved mental health is as smooth as possible. It's like finding the best path through the desert, ensuring a safe and comfortable journey.

The Importance of Tolerability

This research highlights the importance of considering not only the efficacy of antidepressants but also their tolerability. It's not just about achieving symptom relief but also about finding a medication that is well-tolerated and minimizes side effects. This research emphasizes the need for a holistic approach to treatment, considering both the benefits and the potential downsides of each medication. It's like finding an oasis that provides not only water but also a peaceful and comfortable resting place.

Dr.Camel's Conclusion

This network meta-analysis has the potential to provide valuable insights into the safety and efficacy of different antidepressants, guiding both clinicians and patients on their journey toward mental well-being. The desert of antidepressant research is vast and complex, and this study is a step towards finding the best path through this challenging landscape.

Date :
  1. Date Completed 2019-12-09
  2. Date Revised 2023-09-13
Further Info :

Pubmed ID

30996028

DOI: Digital Object Identifier

PMC10270374

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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