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Early side-effects of antihypertensive therapy: comparison of amlodipine and nifedipine retard.

Author: BremnerA D, FellP J, HosieJ, JamesI G, SaulP A, TaylorS H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amlodipine and nifedipine retard were equally effective in treating mild hypertension in 97 patients. However, amlodipine was associated with significantly fewer side effects, such as headache and flushing, during the first 14 days of treatment.
Paper Details　
Original Abstract of the Article :
In a multicentre crossover study of 97 patients with mild hypertension, the incidence and severity of adverse effects were observed during the first 14 days of treatment with amlodipine, nifedipine retard or placebo. Amlodipine (5 mg) once daily was equipotent to nifedipine retard (20 mg) twice dail...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8450526

データ提供：米国国立医学図書館（NLM）

Early Side-Effects of Amlodipine and Nifedipine Retard in Hypertension Treatment

In the vast desert of cardiovascular research, finding effective and safe treatments for hypertension is a constant quest. This research investigates the early side-effects of two commonly used antihypertensive medications, amlodipine and nifedipine retard, in a [study design] involving [number of participants]. The researchers observed that amlodipine, at a dose of [dose], was equally effective as nifedipine retard at [dose]. However, they found that nifedipine retard had a significantly higher incidence of adverse effects, particularly headache and flushing, during the initial 14 days of treatment, compared to amlodipine and placebo. This finding suggests that amlodipine may be a better choice for patients who are sensitive to vasodilatory side effects.

Amlodipine: A More Tolerable Option for Hypertension

The research clearly demonstrates that amlodipine has a lower incidence of adverse effects, particularly vasodilatory side-effects, compared to nifedipine retard. This finding is particularly significant as it suggests that amlodipine might be a more tolerable option for patients with hypertension, especially during the initial phase of treatment.

Choosing the Right Antihypertensive: A Balancing Act

The choice of antihypertensive medication is a delicate balancing act. While both amlodipine and nifedipine retard can effectively lower blood pressure, the potential for side effects, particularly during the initial phase of treatment, should be carefully considered. If you are diagnosed with hypertension, consult with your doctor to discuss the best treatment option for you.

Dr.Camel's Conclusion

This research highlights the importance of considering the potential side effects of antihypertensive medications, especially during the initial phase of treatment. Amlodipine's lower incidence of adverse effects compared to nifedipine retard suggests that it might be a more comfortable choice for some patients. Ultimately, the best choice of medication should be tailored to the individual patient's needs and preferences.

Date :
  1. Date Completed 1993-04-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8450526

DOI: Digital Object Identifier

8450526

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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