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d-Amphetamine versus methylphenidate effects in depressed inpatients.

Author: LittleK Y

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This article discusses the use of d-amphetamine and methylphenidate, two stimulants used to treat ADHD, for treating depression. Both medications can improve mood in some patients, although they have distinct neurochemical effects. This suggests that individuals with depression may respond differently to each stimulant, emphasizing the need for personalized treatment approaches.
Paper Details　
Original Abstract of the Article :
Both d-amphetamine and methylphenidate cause similar behavioral and subjective effects and can relieve depressive symptoms in some patients. However, the neurochemical effects of d-amphetamine and methylphenidate are distinct, and clinical experience suggests that individual depressed patients may r...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8407854

データ提供：米国国立医学図書館（NLM）

d-Amphetamine vs. Methylphenidate: Two Stimulants, Two Different Desert Landscapes

Depression, a common mental health condition, can be like a sandstorm in the mind, obscuring clarity and joy. Stimulants like d-amphetamine and methylphenidate are often used to treat depression, offering a potential oasis of relief. However, these drugs differ in their effects, much like two distinct desert landscapes: d-amphetamine and methylphenidate create unique mental journeys. This study compared the effects of these two stimulants on depressed inpatients, examining their behavioral, subjective, and neurochemical impacts.

A Tale of Two Stimulants: Different Paths to Relief

The study found that d-amphetamine and methylphenidate produced similar behavioral and subjective effects, offering potential relief from depressive symptoms. However, their neurochemical mechanisms differed, suggesting that individual patients might respond differently to each stimulant. It's like choosing a path in the desert: one path might lead to a lush oasis, while another might lead to a barren wasteland. The study emphasizes the importance of personalized treatment approaches when using these stimulants.

Finding the Right Path: Personalized Treatment for Depression

This research highlights the need for a tailored approach to treating depression with stimulants. Just like a camel needs to choose the right path in the desert, patients need to find the right stimulant that aligns with their individual needs and neurochemistry. By understanding the unique effects of each stimulant, healthcare professionals can provide more personalized and effective treatment for depression.

Dr. Camel's Conclusion

Depression, like a desert sandstorm, can be a challenging experience. While d-amphetamine and methylphenidate offer potential relief, they work through different pathways. It's essential to find the right stimulant for each individual, like choosing the right path in a vast desert. This research underscores the importance of personalized treatment approaches for depression, recognizing that one size does not fit all.

Date :
  1. Date Completed 1993-11-16
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

8407854

DOI: Digital Object Identifier

8407854

SNS
PICO Info
in preparation
Languages

English

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