Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunteers.

Author: DixonR M, EvansD H, MeireH B, OnN, PosnerJ, RolanP E, WattH

Paper Details 
Original Abstract of the Article :
Members of the new class of antimigraine compounds, 5HT1B/1D agonists, as well as ergotamine, may cause vasoconstriction through stimulation of 5HT receptors on peripheral vessels. The cardiovascular effects of 20 mg oral zolmitriptan (Zomig, formerly 311C90), 2 mg oral ergotamine and the combinatio...See full text at original site
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引用元:
https://doi.org/10.1046/j.1468-2982.1997.1706639.x

データ提供:米国国立医学図書館(NLM)

Peripheral Vascular Effects of Zolmitriptan and Ergotamine

The world of medicine is constantly seeking new solutions for various ailments, much like a caravan traversing a vast desert in search of a nourishing oasis. This study explores the peripheral vascular effects of two antimigraine drugs, zolmitriptan and ergotamine, when used alone and in combination. It's like studying the intricate vascular network within the body, understanding how these drugs might affect blood flow and vessel diameter.

A Detailed Look at Vascular Effects

The research reveals that both zolmitriptan and ergotamine, despite their potential for vasoconstriction, have minimal effects on blood pressure and blood flow when used at therapeutic doses. This suggests that these drugs can be used safely in combination, offering a potential advantage in treating migraine headaches. It's like navigating a delicate balance within the body, ensuring that the effects of these drugs are carefully controlled.

Finding Harmony in the Desert of Migraine Treatment

This study provides valuable insights into the combined use of zolmitriptan and ergotamine for migraine treatment. It suggests that these drugs can be used together safely and effectively, potentially offering a more comprehensive approach to managing migraine headaches. It's like finding a harmonious blend of herbs and spices in the desert, creating a unique and effective remedy.

Dr.Camel's Conclusion

This study on the peripheral vascular effects of zolmitriptan and ergotamine offers valuable insights into the safe and effective combination of these antimigraine drugs. It's a testament to the ongoing search for new and effective treatment strategies for migraine headaches, like a caravan continuously exploring the vast desert, seeking out new oases of knowledge and relief.

Date :
  1. Date Completed 1997-12-09
  2. Date Revised 2017-02-14
Further Info :

Pubmed ID

9350383

DOI: Digital Object Identifier

10.1046/j.1468-2982.1997.1706639.x

SNS
PICO Info
in preparation
Languages

English

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