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The interaction between propranolol and the novel antimigraine agent zolmitriptan (311C90).

Author: DixonR, GillotinC G, LaytonG, PeckR W, PosnerJ, SeaberE J, WeatherleyB C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the effects of propranolol on the pharmacokinetics and cardiovascular responses to zolmitriptan, a selective 5HT1B/1D agonist used to treat migraine.
Paper Details　
Original Abstract of the Article :
Zolmitriptan (Zomig, formerly known as 311C90), a selective 5HT1B/1D agonist is under development as an acute oral treatment for migraine. Despite the use of prophylactic medication, such as propranolol, breakthrough attacks often occur in patients. Consequently we investigated the effects of propra...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2125.1997.t01-1-00632.x

データ提供：米国国立医学図書館（NLM）

The Interplay of Propranolol and Zolmitriptan: Navigating Migraine Treatment

Migraine, a debilitating headache disorder, can be a relentless desert storm, leaving sufferers feeling lost and overwhelmed. This research explores the interaction between propranolol, a common migraine prophylactic medication, and zolmitriptan, a new antimigraine agent. The study investigates the potential effects of propranolol on the pharmacokinetics and cardiovascular responses to zolmitriptan.

Propranolol and Zolmitriptan: A Complex Desert Landscape

The findings revealed that propranolol did not significantly alter the pharmacokinetics of zolmitriptan, indicating that the two medications can be used together without affecting their absorption or elimination. However, the study also found that propranolol enhanced the cardiovascular responses to zolmitriptan, suggesting that caution is needed when co-administering these medications. It's like navigating a complex desert landscape, where the presence of one element can alter the impact of another.

Navigating Migraine Treatment with Caution

This research highlights the importance of careful monitoring when co-administering propranolol and zolmitriptan. The study underscores the need for healthcare professionals to be aware of the potential for enhanced cardiovascular effects and to adjust treatment strategies as needed to ensure patient safety. It's a reminder that managing migraine requires a comprehensive approach, carefully considering the interplay of different medications and their potential interactions.

Dr.Camel's Conclusion

This research sheds light on the complex interplay between propranolol and zolmitriptan in migraine treatment. It highlights the importance of careful monitoring and individualized treatment strategies to ensure patient safety and optimize therapeutic outcomes.

Date :
  1. Date Completed 1998-02-11
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

9431839

DOI: Digital Object Identifier

10.1046/j.1365-2125.1997.t01-1-00632.x

SNS
PICO Info
in preparation
Languages

English

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