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Effects of Combined Varenicline With Nicotine Patch and of Extended Treatment Duration on Smoking Cessation: A Randomized Clinical Trial.

Author: BakerTimothy B, BoltDaniel M, FioreMichael C, PiperMegan E, SmithStevens S, SteinJames H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This randomized clinical trial found no significant difference in smoking cessation rates at 52 weeks between varenicline monotherapy and combined varenicline plus nicotine patch therapy, or between 12-week and 24-week treatment durations.
Paper Details　
Original Abstract of the Article :
IMPORTANCE: Smoking cessation medications are routinely used in health care. Research suggests that combining varenicline with the nicotine patch, extending the duration of varenicline treatment, or both, may increase cessation effectiveness. OBJECTIVE: To compare combinations of varenicline plus t...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527361/

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Smoking Cessation: A Desert of Trials and Tribulations

We embark on a journey through the vast desert of smoking cessation research, aiming to decipher the secrets of effective cessation strategies. This study, a double-blind, 2×2 factorial randomized clinical trial, investigates the effects of combining varenicline with a nicotine patch, and extending treatment duration on smoking cessation. The researchers, like intrepid explorers navigating treacherous sands, discovered that neither combining varenicline with a nicotine patch nor extending treatment duration significantly increased the likelihood of quitting smoking. Their findings offer valuable insights into the complex terrain of smoking cessation.

A Desert Mirage of Combined Therapy: The Journey Continues

This research suggests that the current practices of combining varenicline and nicotine patches, or extending treatment duration, may not be the most effective paths to smoking cessation. The study found no significant difference in quitting rates between the various treatment groups. This finding could be a desert mirage, prompting a redirection of efforts towards alternative strategies.

Navigating the Desert of Smoking: Finding Oasis of Support

The quest to quit smoking is a challenging one, and this research reinforces the need for personalized approaches. While this study provides valuable insights, it's crucial to remember that individual experiences vary greatly. Seeking support from healthcare professionals, including counseling and alternative therapies, can be essential in navigating the desert of smoking.

Dr.Camel's Conclusion

The search for effective smoking cessation strategies continues. This research, while not discovering a magic bullet, provides valuable insights into the complexities of the journey. The desert of smoking cessation is vast and unforgiving, but with continued research and support, a path to freedom from nicotine can be found.

Date :
  1. Date Completed 2021-10-27
  2. Date Revised 2022-09-14
Further Info :

Pubmed ID

34665204

DOI: Digital Object Identifier

PMC8527361

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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