Effects of calcitonin salmon injection: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Paroxetine, a selective serotonin reuptake inhibitor (SSRI), has been shown to be an effective treatment for depression in several studies. 5 6 In a 6-week double-blind study comparing paroxetine to imipramine and placebo, paroxetine was found to be significantly superior to placebo in relieving depression, with no significant difference in efficacy compared to imipramine. 6 Paroxetine has also been shown to be well-tolerated, with fewer side effects than traditional tricyclic antidepressants like imipramine. 9 3 13 7

While paroxetine is generally considered effective, its antidepressant effect may be weaker compared to other medications like clomipramine. 8 In a controlled multicenter study, clomipramine demonstrated a significantly better therapeutic effect than paroxetine, starting from the second week of treatment. 8 14 27 It's important to note that this study was conducted with hospitalized patients, while many other studies focused on outpatients. Furthermore, paroxetine's effectiveness might vary depending on the duration of treatment. A meta-analysis revealed that paroxetine outperformed fluoxetine in a 6-week treatment period, but fluoxetine showed greater efficacy over a 12-week period. 27

Paroxetine has also been studied for its potential to improve sleep quality, especially in individuals with insomnia. 18 23 One study found that paroxetine combined with zolpidem (a hypnotic) was significantly more effective than paroxetine alone in reducing insomnia symptoms, and also resulted in greater improvements in depression and anxiety scores. 23 However, other studies indicate that paroxetine can disrupt sleep, especially during the withdrawal phase. 18

Paroxetine's impact on cognitive functions is another area of research. While some studies suggest that paroxetine might impair delayed recall, 19 others report that paroxetine might improve cognitive functions in depressed patients. 2 A study comparing paroxetine and sertraline on healthy elderly volunteers revealed that paroxetine was associated with mild behavioral impairment, while sertraline led to mild and transient behavioral changes. 20

Regarding cardiovascular effects, paroxetine has shown lower cardiovascular toxicity compared to traditional tricyclic antidepressants. 1 It has no significant effects on heart rate, blood pressure, or electrocardiogram in healthy men. 1

Paroxetine has also been studied in the treatment of social anxiety disorder. One study found that combining paroxetine with mirtazapine might be more effective and lead to fewer sexual side effects than paroxetine alone in patients who did not respond to either mirtazapine or placebo. 26

Benefits and Risks

Benefit Summary

Paroxetine can be an effective treatment for depression. 5 6 It has been shown to be well-tolerated and have fewer side effects compared to traditional antidepressants. 9 3 13 7 It might also improve sleep quality and reduce anxiety symptoms. 23 6 13 7

Risk Summary

Potential side effects of paroxetine include nausea, indigestion, drowsiness, and sexual dysfunction. 15 26 Like other SSRIs, paroxetine can cause serotonin syndrome. 18 The safety of paroxetine during pregnancy is not fully established. 20 Paroxetine can interact with other medications. 20

Comparison of Studies

Commonalities

Many studies show that paroxetine is effective in treating depression. 5 6 Multiple studies also indicate that paroxetine is generally well-tolerated and has fewer side effects than traditional antidepressants. 9 3 13 7

Differences

Research on the cognitive effects of paroxetine reveals mixed results. Some studies suggest that paroxetine might impair delayed recall, 19 while others show it may improve cognitive functions in depressed patients. 2 A study involving healthy elderly volunteers indicated that paroxetine might have a greater impact on behavioral impairment compared to sertraline. 20 In contrast, paroxetine's effects on sleep are also inconsistent, with some studies suggesting sleep disruption, particularly during withdrawal, 18 while others point to improvements in sleep quality. 23

Consistency and Contradictions of Results

While the majority of research supports paroxetine's effectiveness in treating depression, 5 6 3 13 7 there are inconsistencies in the data regarding its efficacy compared to other SSRIs, 8 and its effects on cognitive functions and sleep. More research is needed to clarify these inconsistencies.

Practical Application

Paroxetine can be a viable treatment option for depression under the guidance of a healthcare professional. 5 6 However, it's crucial to be aware of potential side effects and interactions with other medications. 15 26 20 It's essential to discuss any concerns with your doctor.

Limitations of Current Research

More research is needed to fully understand the efficacy and safety of paroxetine, particularly its relative effectiveness compared to other SSRIs, and its impact on sleep and cognitive function. Further studies are also required to investigate the long-term effects of paroxetine.

Future Research Directions

Future research should aim to address the inconsistencies in the data regarding paroxetine's efficacy and side effect profile. This would require larger-scale, well-designed studies comparing paroxetine to other SSRIs, as well as investigations into its long-term effects and interactions with other medications.

Conclusion

Paroxetine is a potential treatment option for depression, with a generally favorable side effect profile. 5 6 9 However, more research is needed to better understand its long-term effects and interactions with other medications. It's crucial to discuss any concerns about paroxetine with your doctor.

Literature analysis of 27 papers
Positive Content
24
Neutral Content
1
Negative Content
2
Article Type
26
1
0
3
27
1.

Cardiovascular effects of antidepressants: studies of paroxetine in healthy men and depressed patients.

Author: WarringtonS J, LewisY

Fewer cardiovascular side effects
No haemodynamic effects

Paroxetine was found to have similar efficacy to tricyclic antidepressants in treating depression, but with fewer cardiovascular side effects. It lacked any significant haemodynamic or electrophysiological effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

A review of the psychomotor effects of paroxetine.

Author: HindmarchI

Fewer side effects
Improved cognitive function

Paroxetine was found to have no detrimental effects on cognitive function or sleep quality in healthy volunteers and patients with major depressive illness, even when combined with alcohol. In contrast, amitriptyline and lorazepam produced significant impairment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Paroxetine and imipramine in the treatment of depressive patients in psychiatric practice.

Author: OhrbergS, ChristiansenP E, SeverinB, CalbergH, NilakantanB, BorupA, SøgaardJ, LarsenS B, LoldrupD, BahrB

Depression treatment
Well-tolerated
Weight gain

Paroxetine was more effective than imipramine in treating depression in 151 outpatients. Paroxetine also had fewer and less severe side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A placebo-controlled trial of paroxetine in the treatment of major depression.

Author: SmithW T, GlaudinV

Depression treatment
Reduced suicidal ideation

Paroxetine, a selective serotonin reuptake inhibitor, showed greater improvement than placebo in treating moderate to severe major depression, but the differences were not statistically significant. However, it was more effective in patients with long-term depression and resulted in a significant reduction in suicidal ideation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients.

Author: FabreL F

Depression treatment
Few side effects

Paroxetine, a selective serotonin reuptake inhibitor, was significantly superior to placebo in treating major depression in a double-blind study. It was comparable to imipramine in efficacy, but had fewer anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Paroxetine in major depression: a double-blind trial with imipramine and placebo.

Author: CohnJ B, WilcoxC S

Anxiety relief
Depression relief
Few side effects

Paroxetine, a selective serotonin reuptake inhibitor, was superior to placebo in relieving depression and anxiety in patients with major depression. It was comparable to imipramine in efficacy but had fewer anticholinergic side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

A comparison of paroxetine, imipramine and placebo in depressed out-patients.

Author: DunbarG C, CohnJ B, FabreL F, FeighnerJ P, FieveR R, MendelsJ, ShrivastavaR K

Antidepressant effect
Side effects

Paroxetine and imipramine, antidepressants, were both significantly more effective than placebo in treating depression in 240 and 237 patients, respectively. Paroxetine was associated with fewer side effects and a possible earlier antidepressant effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. Danish University Antidepressant Group.

Author:

Antidepressant effect
Adverse reactions
Lack of effect
Mania

Clomipramine was more effective than paroxetine for treating major depressive disorder in a double-blind, randomized inpatient study. Clomipramine showed a significantly better therapeutic effect from the second week of treatment. However, it had more adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Paroxetine in the treatment of depression--a randomized comparison with amitriptyline.

Author: LaursenA L, MikkelsenP L, RasmussenS, le Fèvre HonoréP

Antidepressant
Dry mouth
Orthostatic dizziness

Paroxetine and amitriptyline showed no significant differences in overall antidepressant efficacy in 44 patients with depressive illnesses. Paroxetine had fewer instances of dry mouth and orthostatic dizziness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers.

Author: McClellandG R, RaptopoulosP

Antidepressant effect

Paroxetine, a selective serotonin reuptake inhibitor, significantly altered the EEG in normal volunteers, decreasing delta and theta activity and increasing beta activity. These changes persisted 72 hours after treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

[Antidepressives and traffic safety].

Author: HerbergK W

Concentration problems
Loss of vigilance
Motor coordination problems
Reaction time problems

Paroxetine, an antidepressant, was found to have no significant effect on safety-relevant performance compared to placebo, while doxepin, another antidepressant, impaired vigilance, motor coordination, and concentration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

12.

A 12-week double-blind multi-centre study of paroxetine and imipramine in hospitalized depressed patients.

Author: ArminenS L, IkonenU, PulkkinenP, LeinonenE, MahlanenA, KoponenH, KourulaK, RyyppöJ, KorpelaV, LehtonenM L

Effective antidepressant
No side effects
Well tolerated
Reduced salivation

Paroxetine was as effective as imipramine in treating major depression with better tolerability, showing fewer side effects and a higher proportion of patients without side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

A study comparing paroxetine placebo and imipramine in depressed patients.

Author: FeighnerJ P, CohnJ B, FabreL F, FieveR R, MendelsJ, ShrivastavaR K, DunbarG C

Treats anxiety
Treats depression
Side effects

Paroxetine and imipramine were both effective for depression, but paroxetine may have a greater and earlier effect on anxiety. Paroxetine side effects were similar to other serotonin reuptake inhibitors, but different from those of imipramine, with fewer anticholinergic and cardiovascular symptoms and less premature withdrawal.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Double-blind multicenter study of paroxetine and amitriptyline in depressed inpatients.

Author: MöllerH J, BerzewskiH, EckmannF, GonzalvesN, KisslingW, KnorrW, ResslerP, RudolfG A, SteinmeyerE M, MagyarI

Antidepressant efficacy
Anticholinergic effects
Nausea

This study found that paroxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, was equally effective as amitriptyline, a tricyclic antidepressant, at treating major depression. Both drugs had characteristic side effects, with paroxetine causing less anticholinergic effects but more nausea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

A comparison of paroxetine and placebo in depressed outpatients.

Author: DunbarG C, ClaghornJ L, KievA, RickelsK, SmithW T

Good tolerability
Improved depression symptoms
Common side effects

Paroxetine was effective in treating major depression and well-tolerated, with side effects similar to other serotonin reuptake inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Duplicate PublicationPublishing the same research/results in multiple journals/publications without proper disclosure/permission.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

A double-blind, multicentre study of paroxetine and maprotiline in major depression.

Author: SchnyderU, Koller-LeiserA

Comparable side effects
Similar efficacy

Paroxetine and maprotiline showed similar efficacy and side effect profiles in patients with major depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Paroxetine in the treatment of Chinese patients with depressive episode: a double-blind randomized comparison with imipramine.

Author: ChiuH J, HongC J, ChanC H

Effective for depression
Fewer anticholinergic effects
Anticholinergic effects
Impatience

Paroxetine was found to be as effective as imipramine in treating depression in Chinese patients, but with fewer anticholinergic adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: a home-based Nightcap evaluation during drug administration and withdrawal.

Author: SilvestriR, Pace-SchottE F, GershT, StickgoldR, SalzmanC, HobsonJ A

Sleep disruption

Paroxetine disrupted sleep more than fluvoxamine, and sleep disruption persisted into the withdrawal phase in healthy volunteers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Non-serotonergic pharmacological profiles and associated cognitive effects of serotonin reuptake inhibitors.

Author: SchmittJ A, KruizingaM J, RiedelW J

Improved verbal fluency
Impaired memory

Paroxetine, a serotonin reuptake inhibitor, impaired delayed recall in a word learning test at 20 and 40 mg doses. Sertraline, another serotonin reuptake inhibitor, did not affect word learning but improved performance on a verbal fluency task at 50 and 100 mg doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Cognitive and psychomotor effects of paroxetine and sertraline on healthy elderly volunteers.

Author: FurlanP M, KallanM J, Ten HaveT, PollockB G, KatzI, LuckiI

Improved cognitive function
Behavioral impairment

This study evaluated the cognitive and psychomotor effects of paroxetine and sertraline in healthy elderly volunteers. Results showed that paroxetine was associated with mild behavioral impairment, while sertraline was associated with mild and transient behavioral changes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression.

Author: GoldenRobert N, NemeroffCharles B, McSorleyPaul, PittsCornelius D, DubéEric M

Improved tolerability

Paroxetine controlled-release (CR) has been developed to improve general tolerability, particularly gastrointestinal tolerability, in patients taking antidepressants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Tolerance and side-effects of paroxetine in elderly depressed patients.

Author: GhoseK

Improved mood
Well tolerated
Gastrointestinal symptoms
Skin rash

Paroxetine is an antidepressant that has fewer side effects than other antidepressants. A study of 12 elderly patients found that paroxetine was well-tolerated at doses of 15mg and 30mg per day. There were no significant changes in blood pressure, heart rate, or other measures of function. However, patients in the 30mg group showed a significant improvement in their symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

[Effects of paroxetine with or without zolpidem on depression with insomnia: a multi-center randomized comparative study].

Author: JiJian-Lin, LiuWen-Juan, ZhangNing, ChenZhi-Qing, ZhengAn-Lin, MeiQi-Yi, PanJi-Yang, ZhaoZhong-Xin, TaoMing, WangYu-Ping, WeiJing

Depression treatment
Insomnia treatment

Adding a hypnotic (zolpidem) to a selective serotonin reuptake inhibitor (SSRI) antidepressant (paroxetine) significantly enhanced the antidepressant's effects on depressive and anxiety symptoms in patients with depression and insomnia. The combination therapy resulted in greater improvements in sleep quality, depression severity, and anxiety levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

24.

Investigating the efficacy of paroxetine in developmental stuttering.

Author: BusanPierpaolo, BattagliniPiero Paolo, BorelliMassimo, EvaristoPasquale, MontiFabrizio, PelamattiGiovanna

Stuttering symptom management
None mentioned

Paroxetine may be useful in qualitative management of stuttering symptoms. Paroxetine administration shortened the cortical silent period (CSP) with no effect on motor thresholds, suggesting that it may act on the stuttering brain by diminishing intracortical inhibition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Effects of paroxetine on emotional functioning and treatment awareness: a 4-week randomized placebo-controlled study in healthy clinicians.

Author: BesnierNathalie, Cassé-PerrotCatherine, JouveElisabeth, NguyenNhan, LançonChristophe, FalissardBruno, BlinOlivier

Emotional Functioning Improvement

Paroxetine, an antidepressant, did not significantly impact emotional functioning in healthy individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Paroxetine augmentation in patients with generalised social anxiety disorder, non-responsive to mirtazapine or placebo.

Author: SchuttersSara I J, van MegenHarold J G M, Van VeenJ Frederieke, SchruersKoen R J, WestenbergHerman G M

Reduced sexual dysfunction

Combining mirtazapine with paroxetine did not show a greater efficacy than paroxetine alone in treating social anxiety disorder (SAD). However, the combination treatment was associated with less sexual dysfunction compared to paroxetine alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Comparative efficacies of fluoxetine and paroxetine in major depression across varying acute-phase treatment periods: a meta-analysis.

Author: WangYing, YuLehua, XieJing, ChenJianjun, WeiQianping

Effective for depression
Pseudoresistance

A meta-analysis of 17 studies comparing fluoxetine and paroxetine for depression found that paroxetine was more efficacious than fluoxetine in the 6-week subgroup, while fluoxetine was more efficacious than paroxetine in the 12-week subgroup. Both drugs displayed comparable efficacy in the 8/10-week subgroup. These findings suggest that the duration of acute-phase treatment is a significant factor in the efficacy of these antidepressants.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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