Effective treatment of angioplasty: A Synthesis of Findings from 38 Studies

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This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Multiple studies have shown that angioplasty is an effective treatment for peripheral artery disease and heart disease. Angioplasty is a procedure that opens blocked arteries. Specific methods of angioplasty include 4 , 22 , 35 , 37 , 10 , 31 , 28 , 6 , 33 , 1 , 3 , 5 , 32 , 2 , 7 , 12 , 16 , 24 , 26 , 29 , 18 , 30 , 11 , 19 , 9 , 14 , 27 , 13 , 15 , 34 , 36 , 23 , 8 , 21 , 38 , 25 , 20 , 17 and so on.

For example, the study 4 compared angioplasty and surgery for peripheral artery disease. The results showed that angioplasty has a higher initial failure rate than surgery, while surgery has a risk of death and complications. However, there was no significant difference in the long-term death or leg amputation rates between angioplasty and surgery.

The study 22 compared angioplasty and thrombolysis for acute myocardial infarction. The results showed that angioplasty has a lower rate of re-occlusion of the infarct-related artery than thrombolysis. This suggests that angioplasty is an effective option for treating acute myocardial infarction. The study 35 found that angioplasty with a drug-coated balloon has a lower restenosis rate than conventional angioplasty. These research results indicate that angioplasty has a high treatment effect, but there are also risks such as restenosis.

Treatment Summary

The study 4 compared angioplasty and surgery for peripheral artery disease. The study 22 compared angioplasty and thrombolysis for acute myocardial infarction. Additionally, the study 35 introduced angioplasty using a drug-coated balloon. These studies show that angioplasty is an effective treatment option for various diseases such as peripheral artery disease and myocardial infarction.

Benefits and Risks

Benefit Summary

Angioplasty is an effective way to treat diseases such as peripheral artery disease and myocardial infarction. Angioplasty can reopen blocked arteries, improving blood flow. This leads to symptom improvement and improved quality of life. Angioplasty is also less invasive and has a faster recovery time than surgery.

Risk Summary

Angioplasty has risks such as restenosis, bleeding, and thrombosis. Restenosis is the narrowing of the treated artery after the procedure. Bleeding can occur during the procedure when the artery is damaged. Thrombosis is the formation of a blood clot in the artery.

Comparison of Studies

Commonalities in Studies

These studies indicate that angioplasty is a valuable treatment option for various diseases. It’s also common to see a risk of restenosis, bleeding, and other complications associated with angioplasty.

Differences in Studies

These studies differ in their subject diseases and treatment methods, making direct comparison difficult. For example, the study 4 compared angioplasty and surgery for peripheral artery disease. In contrast, the study 22 compared angioplasty and thrombolysis for acute myocardial infarction. Also, the study 35 presented angioplasty using a drug-coated balloon.

Consistency and Contradictions in Results

These studies have demonstrated that angioplasty is effective in treating various diseases. However, some studies have shown that angioplasty is superior to surgery. Other studies have found no significant difference in the effects between angioplasty and surgery. Further research is needed to resolve these contradictions.

Considerations for Applying Results to Daily Life

Angioplasty is an effective method for treating various diseases, but it’s important to remember that it comes with risks like restenosis and bleeding. It’s crucial to discuss your condition and risks with your doctor before considering angioplasty.

Limitations of Current Research

These studies have limitations such as a small number of subjects and short follow-up periods. Therefore, we can't directly apply these research results to everyday life. Further research is necessary.

Directions for Future Research

Future research should focus on further validating the safety and efficacy of angioplasty. Specifically, research is needed on methods to reduce the risk of restenosis and on the long-term outcomes after angioplasty.

Conclusion

Angioplasty is an effective treatment option for various diseases, such as peripheral artery disease and myocardial infarction. However, it’s important to remember that angioplasty comes with risks like restenosis and bleeding. It’s essential to consult your doctor about your condition and risks before considering angioplasty.

Treatment List

Angioplasty, Surgery, Thrombolysis, Drug-coated balloon angioplasty.

Keywords
Benefit Keywords
LV function improvement
Myocardial infarction treatment
1
BA treatment
Clinical success
3
Improved blood flow
Reduced amputation risk
4
Reduced complications
5
left ventricular function
myocardial infarction treatment
6
Improved blood flow
Recanalized artery
7
Angina treatment
8
Thrombolytic therapy for claudication
9
Improved unstable angina treatment
10
Symptomatic improvement
11
Increased coronary patency
12
Femoropopliteal occlusion treatment
13
Angiographic patency
Reduced technical failure
14
Improved angiographic outcomes
Improved patient stability
Reduced anginal pain
Reduced balloon usage
15
Cost-effective
Improved survival
16
Myocardial infarction treatment
17
Reduced angina
18
Peripheral artery disease treatment
19
Multivessel disease treatment
20
Advantages of primary angioplasty
21
Improved blood flow
Reduced mortality
22
Myocardial infarction treatment
23
Angina improvement
Exercise tolerance
24
Coronary artery disease treatment
25
Better myocardial perfusion
Improved patency
26
PAD treatment
27
Myocardial infarction treatment
28
Reduced cranial neuropathy
Reduced neurological complications
29
Improved technical success
30
Intracranial atherosclerotic disease treatment
31
Treatment of PAD
32
Improved patency
33
Reduced restenosis
34
Improved vessel patency
Reduced restenosis
35
Improved blood flow
Reduced ICAD
37
Improved BPA technique
38
Risk Keywords
Reocclusion
1
Angioplasty effectiveness
High mortality
2
Small dissections
3
Death
Surgical complications
4
Restenosis
5
myocardial infarction
6
Hemorrhagic complications
7
Restenosis
8
Peripheral embolization
9
Procedure-related complications
11
Early reocclusion
Tibioperoneal artery occlusion
13
Early thrombosis
14
Residual angina
16
Persistent occlusion
Reocclusion
17
Increased coronary artery bypass grafting
Increased death risk
Increased stroke risk
18
Repeated revascularization
20
Delay of treatment caused by transportation
21
Ineligible patients
Persistent occlusion
22
Death
MI
Re-intervention
24
No effect on clinical outcome
26
Restenosis/reocclusion
27
Increased stroke risk with surgery
29
Death
Restenosis
Stroke
30
Provisional stenting
33
Pulmonary vascular injury
38
Literature analysis of 38 papers
Positive Content
34
Neutral Content
2
Negative Content
2
Article Type
23
11
10
10
37
1.

[Direct angioplasty without previous fibrinolytic treatment during the 1st hours following myocardial infarction].

Author: MarcoJ, FajadetJ, RobertG, CassagneauB

LV function improvement
Myocardial infarction treatment
Reocclusion

Direct coronary angioplasty performed as an emergency procedure for myocardial infarction without prior thrombolytic therapy has a high recanalization rate (90%) but an acceptable hospital mortality rate (7%). The reocclusion rate is 10-15%. Long-term survival rates are excellent for single-vessel disease, but lower for multivessel disease. Angioplasty performed within the first 3 hours may improve left ventricular function. A multicenter trial comparing direct angioplasty with intravenous thrombolytic therapy is ongoing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

2.

Present status of rescue coronary angioplasty: current polarization of opinion and randomized trials.

Author: EllisS G, Van de WerfF, Ribeiro-daSilvaE, TopolE J

Angioplasty effectiveness
High mortality

The clinical benefit of rescue angioplasty after failed thrombolytic treatment for acute myocardial infarction remains unproven in randomized trials. Nonrandomized data suggest that angioplasty is successful in 80% of cases, but reocclusion rates and left ventricular function may vary. Mortality rates after successful angioplasty are similar to successful thrombolysis, but higher after failed angioplasty. Randomized trials are needed to guide the use of rescue angioplasty.

EditorialAn article in which the editor or publisher expresses their opinion or perspective on a particular topic or issue. Its purpose is to convey a specific message or idea to the reader.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

3.

Recurrence of stenoses following balloon angioplasty and Simpson atherectomy of the femoro-popliteal segment. A randomised comparative 1-year follow-up study using colour flow duplex.

Author: VroegindeweijD, KemperF J, TielbeekA V, ButhJ, LandmanG

BA treatment
Clinical success
Small dissections

A study of 30 patients with narrowed or blocked leg arteries compared balloon angioplasty (BA) to atherectomy (AT) for treatment. Both procedures improved clinical symptoms, but BA had significantly better long-term results in keeping the arteries open. The one-year patency rate (no narrowing greater than 49%) was 77% for BA compared to 25% for AT. Both procedures had a low rate of complications. The study suggests that BA may be a more effective treatment option for narrowed or blocked leg arteries.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Percutaneous transluminal angioplasty versus operation for peripheral arteriosclerosis. Report of a prospective randomized trial in a selected group of patients.

Author: WilsonS E, WolfG L, CrossA P

Improved blood flow
Reduced amputation risk
Death
Surgical complications

This study compared percutaneous transluminal angioplasty (PTA) with surgery for treating blocked blood vessels in the legs. 255 patients were randomized to receive either treatment. PTA had a 15.5% immediate failure rate, while surgery had a 0.8% in-hospital death rate and 13.5% complication rate. Over 4.5 years, both groups experienced similar rates of death (20%) and major leg amputations (10%). While surgery resulted in a slightly greater improvement in blood flow immediately after treatment, both groups showed similar long-term improvement in blood flow.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

5.

Prevention of post-PTCA restenosis.

Author: FaxonD P, CurrierJ W

Reduced complications
Restenosis

This review of over 40 large randomized pharmacological trials over the past 10 years found that no single agent has been conclusively shown to reduce restenosis following angioplasty.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Primary coronary angioplasty versus intravenous streptokinase in acute myocardial infarction: differences in outcome during a mean follow-up of 18 months.

Author: ZijlstraF, de BoerM J, OttervangerJ P, LiemA L, HoorntjeJ C, SuryapranataH

left ventricular function
myocardial infarction treatment
myocardial infarction

This report discusses the effectiveness of intravenous streptokinase and primary coronary angioplasty in treating patients with acute myocardial infarction. While primary coronary angioplasty is associated with a high patency rate and well-preserved left ventricular function, it is not known whether it results in a more favorable clinical outcome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Primary coronary angioplasty in acute anterior myocardial infarction: immediate results].

Author: GarcíaE J, DelcánJ L, ElízagaJ, AbeytuaM, SorianoJ, García RoblesJ A, BotasJ, López-BescósL, EcheverríaT, BeloscarA

Improved blood flow
Recanalized artery
Hemorrhagic complications

Primary angioplasty is an effective and safe treatment for acute myocardial infarction, with a 90.9% success rate in recanalizing the left anterior descending artery. The procedure was associated with a 6.1% mortality rate and one hemorrhagic complication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Spanish

8.

Randomised trial of excimer laser angioplasty versus balloon angioplasty for treatment of obstructive coronary artery disease.

Author: AppelmanY E, PiekJ J, StrikwerdaS, TijssenJ G, de FeyterP J, DavidG K, SerruysP W, MargolisJ R, KoelemayM J, Montauban van SwijndregtE W, KoolenJ J

Angina treatment
Restenosis

Excimer laser angioplasty followed by balloon angioplasty provides no benefit additional to balloon angioplasty alone with respect to the initial and long-term clinical and angiographic outcome in the treatment of obstructive coronary artery disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Thrombolytic therapy compared with mechanical recanalization in non-acute peripheral arterial occlusions: a randomized trial.

Author: MeyerovitzM F, DidierD, VogelJ J, Soulier-ParmeggianiL, BounameauxH

Thrombolytic therapy for claudication
Peripheral embolization

A short course of thrombolytic therapy prior to angioplasty improved the 1-year patency rate for claudication due to iliac or femoropopliteal occlusions. However, patients with limb-threatening ischemia had a high prevalence of peripheral embolization and dismal patency rates with this form of therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

[Current indications of myocardial revascularization in unstable angina].

Author: DanchinN, AngioïM

Improved unstable angina treatment

Studies have shown that revascularization (surgery or angioplasty) is beneficial for unstable angina, especially for patients with severe blockages in multiple coronary arteries or weakened heart function. Angioplasty has become increasingly common, with promising short-term results, although complications are higher during unstable angina. Adding clot-busting drugs to angioplasty treatment may not be beneficial. However, new antithrombotic medications may reduce risks. Long-term results of angioplasty for unstable angina are similar to those for stable angina, with the likelihood of blockage returning being similar. The best treatment strategy for unstable angina is still under debate. A study found that immediate angioplasty resulted in a shorter hospital stay and fewer readmissions compared to a more conservative approach, but overall outcomes at 6 months were similar.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : French

11.

Coronary angioplasty versus medical therapy for angina: the second Randomised Intervention Treatment of Angina (RITA-2) trial. RITA-2 trial participants.

Author:

Symptomatic improvement
Procedure-related complications

Early intervention with PTCA was associated with greater symptomatic improvement, especially in patients with more severe angina. PTCA was associated with a small excess hazard due to procedure-related complications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Confirmation that heparin is an alternative means of promoting early reperfusion.

Author: BragaJ C, EstevesF P, EstevesJ P, LatadoA L, GodinhoA G, Azevedo JúniorA, BritoJ C, SilvaP R, TeixeiraM S, SouzaV P, Rabelo JúniorA, RochaM S

Increased coronary patency

This study investigated the use of a high-dose heparin bolus as an alternative to chemical thrombolysis before primary angioplasty for patients with occluded infarct-related arteries.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Percutaneous transluminal angioplasty and enclosed thrombolysis versus percutaneous transluminal angioplasty in the treatment of femoropopliteal occlusions: results of a prospective randomized trial.

Author: NicholsonT

Femoropopliteal occlusion treatment
Early reocclusion
Tibioperoneal artery occlusion

Percutaneous transluminal angioplasty combined with enclosed thrombolysis showed no significant advantage over angioplasty alone in treating femoropopliteal occlusions when associated with normal proximal arteries and at least one normal tibioperoneal artery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

[PTA vs. stent in femoro-popliteal obstruction].

Author: CejnaM, SchoderM, LammerJ

Angiographic patency
Reduced technical failure
Early thrombosis

Primary stenting did not improve mid-term angiographic and clinical patency compared to balloon angioplasty alone in treating femoropopliteal obstructive disease.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

15.

Use of the perfusion balloon as a primary dilation device.

Author: PhillipsH R, OhmanE M, LabinazM, SketchM H, StackR

Improved angiographic outcomes
Improved patient stability
Reduced anginal pain
Reduced balloon usage

This study discussed the benefits of using perfusion balloon catheters for prolonged dilations as a primary catheter treatment for coronary artery disease. The study highlights the advantages of this approach in terms of improved angiographic outcomes, reduced pain, and potential for decreased overall balloon usage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Analysis of trials of surgery vs angioplasty in myocardial revascularization.

Author: PrêtreR, TurinaM I

Cost-effective
Improved survival
Residual angina

Surgery and angioplasty resulted in similar overall and infarct-free survival rates at 5 years for low-risk patients. Residual angina was more prevalent after angioplasty, negatively impacting quality of life. Further research is needed for high-risk patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

17.

Primary angioplasty versus intravenous thrombolysis for acute myocardial infarction.

Author: CucheratM, BonnefoyE, TremeauG

Myocardial infarction treatment
Persistent occlusion
Reocclusion

This study highlights the use of intravenous thrombolytic therapy in treating acute myocardial infarction and discusses its limitations, including patient ineligibility and the potential for persistent or recurrent occlusion of the infarct-related artery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

PTA versus Palmaz stent placement in femoropopliteal artery obstructions: a multicenter prospective randomized study.

Author: CejnaM, ThurnherS, IlliaschH, HorvathW, WaldenbergerP, HornikK, LammerJ

Peripheral artery disease treatment

Stent placement did not improve 1-year angiographic and clinical/hemodynamic success in patients with chronic symptoms of short femoropopliteal arterial lesions compared to percutaneous transluminal angioplasty (PTA). The study involved 154 limbs from 141 patients with intermittent claudication or chronic critical limb ischemia. The primary success rate was significantly higher after stent placement, but the long-term benefits were not observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Comparison of coronary-artery bypass surgery and stenting for the treatment of multivessel disease.

Author: SerruysP W, UngerF, SousaJ E, JateneA, BonnierH J, SchönbergerJ P, BullerN, BonserR, van den BrandM J, van HerwerdenL A, MorelM A, van HoutB A,

Multivessel disease treatment
Repeated revascularization

Coronary stenting for multivessel disease is less expensive than bypass surgery and offers the same degree of protection against death, stroke, and myocardial infarction. However, stenting is associated with a greater need for repeated revascularization.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Danish multicenter randomized study on fibrinolytic therapy versus acute coronary angioplasty in acute myocardial infarction: rationale and design of the DANish trial in Acute Myocardial Infarction-2 (DANAMI-2).

Author: AndersenHenning Rud, NielsenTorsten Toftegaard, VesterlundThomas, GrandePeer, AbildgaardUlrik, ThayssenPer, PedersenFlemming, MortensenLeif Spange,

Advantages of primary angioplasty
Delay of treatment caused by transportation

While studies have shown that angioplasty is beneficial for heart attacks when performed immediately at specialized centers, most people with heart attacks are initially treated at hospitals without angioplasty capabilities. Therefore, transferring patients to a specialized center for angioplasty may delay treatment and potentially negate the benefits of angioplasty compared to giving clot-busting medication at the local hospital.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Primary angioplasty versus intravenous thrombolysis for acute myocardial infarction.

Author: CucheratM, BonnefoyE, TremeauG

Improved blood flow
Reduced mortality
Ineligible patients
Persistent occlusion

Primary angioplasty (primary PTCA) has emerged as an alternative to intravenous thrombolytic therapy for myocardial infarction, addressing the limitations of thrombolytic therapy such as ineligibility and reocclusion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction.

Author: AndersenHenning R, NielsenTorsten T, RasmussenKlaus, ThuesenLeif, KelbaekHenning, ThayssenPer, AbildgaardUlrik, PedersenFlemming, MadsenJan K, GrandePeer, VilladsenAnton B, KrusellLars R, HaghfeltTorben, LomholtPreben, HustedSteen E, VigholtElse, KjaergardHenrik K, MortensenLeif Spange,

Myocardial infarction treatment

The study questioned whether the benefit of primary angioplasty over fibrinolysis for patients with myocardial infarction with ST-segment elevation is maintained for patients who require transportation from a community hospital to a center where invasive treatment is available.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Seven-year outcome in the RITA-2 trial: coronary angioplasty versus medical therapy.

Author: HendersonRobert A, PocockStuart J, ClaytonTim C, KnightRosemary, FoxKeith A A, JulianDesmond G, ChamberlainDouglas A,

Angina improvement
Exercise tolerance
Death
MI
Re-intervention

An initial strategy of PTCA did not influence the risk of death or MI, but it improved angina and exercise tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Stent placement compared with balloon angioplasty for obstructed coronary artery disease in Thai elderly patients: initial result and 6 months follow-up.

Author: PanchavinninPradit, TresukosolDamras, PhankingthongkumRewat, SriyuthasakOdthon, SahasakulYongyuth, ThongsawasRampaipan

Coronary artery disease treatment

Percutaneous Old Balloon Angioplasty (POBA) is a safe and quick treatment for obstructive coronary artery disease, but it has a high restenosis rate. Stent placement has been shown to reduce the restenosis rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Facilitation of primary coronary angioplasty by early start of a glycoprotein 2b/3a inhibitor: results of the ongoing tirofiban in myocardial infarction evaluation (On-TIME) trial.

Author: van 't HofArnoud W J, ErnstNicolette, de BoerMenko-Jan, de WinterRob, BoersmaEric, BuntTon, PetronioSonia, Marcel GosselinkA T, JapWalter, HollakFrans, HoorntjeJan C A, SuryapranataHarry, DambrinkJan-Henk E, ZijlstraFelix,

Better myocardial perfusion
Improved patency
No effect on clinical outcome

Early initiation of Tirofiban before PCI did not significantly improve initial TIMI 3 flow. Despite better patency pre-PCI, no beneficial effect on post-PCI angiographic or clinical outcome was found.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Antiplatelet and anticoagulant drugs for prevention of restenosis/reocclusion following peripheral endovascular treatment.

Author: Dörffler-MellyJ, KoopmanM M W, PrinsM H, BüllerH R

PAD treatment
Restenosis/reocclusion

Balloon angioplasty is a common treatment for peripheral artery disease (PAD), but the treated arteries often narrow again (restenosis/reocclusion). This happens more often in longer blockages, poor blood flow in the lower leg, advanced disease, and people with heart disease risk factors. To prevent this, patients are given blood thinners.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

WITHDRAWN: Primary angioplasty versus intravenous thrombolysis for acute myocardial infarction.

Author: CucheratM, BonnefoyE, TremeauG

Myocardial infarction treatment

Primary angioplasty has been proposed as a potential alternative to intravenous thrombolytic therapy for acute myocardial infarction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Percutaneous transluminal angioplasty and stenting for carotid artery stenosis.

Author: EderleJ, FeatherstoneR L, BrownM M

Reduced cranial neuropathy
Reduced neurological complications
Increased stroke risk with surgery

This review found that the data are difficult to interpret because the trials are heterogeneous. The pattern of effects on different outcomes does not support a change in clinical practice away from recommending carotid endarterectomy as the treatment of choice for suitable carotid artery stenosis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

A systematic review on outcome after stenting for intracranial atherosclerosis.

Author: GröschelKlaus, SchnaudigelSonja, PilgramSara M, WasserKatrin, KastrupAndreas

Improved technical success
Death
Restenosis
Stroke

Intracranial stenting appears to be feasible, but adverse events vary widely.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Comparison between primary angioplasty and stent placement for symptomatic intracranial atherosclerotic disease: meta-analysis of case series.

Author: SiddiqFarhan, MemonMuhammad Zeeshan, VazquezGabriela, SafdarAdnan, QureshiAdnan I

Intracranial atherosclerotic disease treatment

This meta-analysis compared the short- and long-term risks of stroke and/or death associated with primary angioplasty alone versus angioplasty with stent placement in treating symptomatic intracranial atherosclerotic disease. The study aimed to determine which endovascular technique is more effective in reducing stroke and death risk.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

32.

Antiplatelet and anticoagulant drugs for prevention of restenosis/reocclusion following peripheral endovascular treatment.

Author: RobertsonLindsay, GhouriMaaz A, KovacsFlora

Treatment of PAD

Balloon angioplasty is a common treatment for narrowing arteries in the legs. The likelihood of the arteries becoming blocked again (restenosis/reocclusion) depends on factors like the length of the blockage, blood flow in the lower legs, severity of the disease, and other heart health risks. Blood thinners are used to help prevent re-blockage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Stent placement versus balloon angioplasty for the treatment of obstructive lesions of the popliteal artery: a prospective, multicenter, randomized trial.

Author: RastanAljoscha, KrankenbergHans, BaumgartnerIris, BlessingErwin, Müller-HülsbeckStefan, PilgerErnst, ScheinertDierk, LammerJohannes, GißlerMartin, NooryElias, NeumannFranz-Josef, ZellerThomas

Improved patency
Provisional stenting

Primary nitinol stent placement for obstructive lesions of the popliteal artery achieves superior acute technical success and higher 1-year primary patency only if provisional stenting is considered target-lesion revascularization. Provisional stenting as part of a percutaneous transluminal balloon angioplasty strategy has equivalent 1-year patency and should be preferred over primary stenting.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

34.

Intravascular brachytherapy for peripheral vascular disease.

Author: AndrasAlina, HansraniMonica, StewartMarlene, StansbyGerard

Reduced restenosis

This review examines the effectiveness of intravascular brachytherapy, which involves directly applying radiation to narrowed and obstructed arteries, in preventing restenosis (narrowing) of vessels and grafts after treatment. The review updates a previous review published in 2002.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Trial of a Paclitaxel-Coated Balloon for Femoropopliteal Artery Disease.

Author: RosenfieldKenneth, JaffMichael R, WhiteChristopher J, Rocha-SinghKrishna, Mena-HurtadoCarlos, MetzgerD Christopher, BrodmannMarianne, PilgerErnst, ZellerThomas, KrishnanPrakash, GammonRoger, Müller-HülsbeckStefan, NehlerMark R, BenenatiJames F, ScheinertDierk,

Improved vessel patency
Reduced restenosis

Percutaneous transluminal angioplasty with a paclitaxel-coated balloon resulted in a higher rate of primary patency at 12 months compared to standard balloon angioplasty. The drug-coated balloon was noninferior to the standard balloon with respect to safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Midterm Outcome of Directional Atherectomy Combined with Drug-Coated Balloon Angioplasty Versus Drug-Coated Balloon Angioplasty Alone for Femoropopliteal Arteriosclerosis Obliterans.

Author: CaiZhiwen, GuoLianrui, QiLixing, CuiShijun, TongZhu, GuoJianming, WangZhonggao, GuYongquan

This study compared the therapeutic effects of directional atherectomy combined with drug-coated balloon (DCB) angioplasty with DCB angioplasty alone in treating femoropopliteal arteriosclerosis obliterans. The study showed that the combination therapy was more effective in improving drug delivery efficiency and therapeutic outcomes compared to DCB angioplasty alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Submaximal angioplasty in the treatment of patients with symptomatic ICAD: a systematic review and meta-analysis.

Author: SeyedsaadatSeyed Mohammad, YolcuYagiz Ugur, NeuhausAin, RizviAsim, AlzuabiMuayad, MuradMohammad H, BrinjikjiWaleed, BydonMohamad, KallmesDavid F

Improved blood flow
Reduced ICAD

Submaximal angioplasty (SA) may be a better option than aggressive medical therapy or stenting for intracranial atherosclerotic disease (ICAD). SA is a promising treatment option for ICAD, offering significant benefits without the risks associated with more aggressive treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Periprocedural Complications With Balloon Pulmonary Angioplasty: Analysis of Global Studies.

Author: JainNishant, SheikhMuhammad A, BajajDivyansh, TownsendWhitney, KrasuskiRichard, SecemskyEric, ChatterjeeSaurav, MolesVictor, AgarwalPrachi P, HaftJonathan, VisovattiScott H, CascinoThomas M, RosenfieldKenneth, NallamothuBrahmajee K, MclaughlinVallerie V, AggarwalVikas

Improved BPA technique
Pulmonary vascular injury

This review examines the evolution of balloon pulmonary angioplasty (BPA) as a treatment modality for patients with inoperable, medically refractory chronic thromboembolic pulmonary hypertension.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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